Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences
Expected and observed effects of volume exclusion on the free energy of rigid and flexible macromolecules in crowded and confined systems, and consequent effects of crowding and confinement on macromolecular reaction rates and equilibria are summarized. Findings from relevant theoretical/simulation...
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| Veröffentlicht in: | Annual review of biophysics 2008-01, Vol.37 (1), p.375-397 |
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| container_title | Annual review of biophysics |
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| creator | Zhou, Huan-Xiang Rivas, Germán Minton, Allen P |
| description | Expected and observed effects of volume exclusion on the free energy of rigid and flexible macromolecules in crowded and confined systems, and consequent effects of crowding and confinement on macromolecular reaction rates and equilibria are summarized. Findings from relevant theoretical/simulation and experimental literature published from 2004 onward are reviewed. Additional complexity arising from the heterogeneity of local environments in biological media, and the presence of nonspecific interactions between macromolecules over and above steric repulsion, are discussed. Theoretical and experimental approaches to the characterization of crowding- and confinement-induced effects in systems approaching the complexity of living organisms are suggested. |
| doi_str_mv | 10.1146/annurev.biophys.37.032807.125817 |
| format | Article |
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| ispartof | Annual review of biophysics, 2008-01, Vol.37 (1), p.375-397 |
| issn | 1936-122X 1936-1238 |
| language | eng |
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| source | Annual Reviews Complete A-Z List; MEDLINE |
| subjects | Biochemistry - methods Biophysics - methods Computer Simulation Models, Chemical Models, Molecular Multiprotein Complexes - chemistry Multiprotein Complexes - physiology Multiprotein Complexes - ultrastructure Physiology - methods Proteins - chemistry Proteins - physiology Proteins - ultrastructure Signal Transduction - physiology Structure-Activity Relationship |
| title | Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences |
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