Effects of Geometric Isomerism and Anions on the Kinetics and Mechanism of the Stepwise Formation of Long-Range DNA Interstrand Cross-Links by Dinuclear Platinum Antitumor Complexes

Reported herein is a detailed study of the kinetics and mechanism of formation of a 1,4‐GG interstrand cross‐link by the dinuclear platinum anticancer compound [15N][{cis‐PtCl(NH3)2}2{μ‐NH2(CH2)6NH2}]2+ (1,1/c,c (1)). The reaction of [15N]1 with 5′‐{d(ATATGTACATAT)2} (I) has been studied by [1H,15N]...

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