Novel model of frontal impact closed head injury in the rat

Frontal impact, closed head trauma is a frequent cause of traumatic brain injury (TBI) in motor vehicle and sports accidents. Diffuse axonal injury (DAI) is common in humans and experimental animals, and results from shearing forces that develop within the anisotropic brain. Because the specific ani...

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Veröffentlicht in:	Journal of neurotrauma 2009-12, Vol.26 (12), p.2233-2243
Hauptverfasser:	Kilbourne, Michael, Kuehn, Reed, Tosun, Cigdem, Caridi, John, Keledjian, Kaspar, Bochicchio, Grant, Scalea, Thomas, Gerzanich, Volodymyr, Simard, J Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Acceleration - adverse effects Amyloid beta-Protein Precursor - metabolism Animal models in research Animals Axons - metabolism Axons - pathology Biomarkers - analysis Biomarkers - metabolism Biomechanical Phenomena Brain Brain - pathology Brain - physiopathology Brain Injuries - metabolism Brain Injuries - pathology Brain Injuries - physiopathology Caspase 3 - metabolism Complications and side effects Diffuse Axonal Injury - metabolism Diffuse Axonal Injury - pathology Diffuse Axonal Injury - physiopathology Disease Models, Animal Frontal Bone - injuries Head injuries Head Injuries, Closed - metabolism Head Injuries, Closed - pathology Head Injuries, Closed - physiopathology Hippocampus - metabolism Hippocampus - pathology Injuries Male Neurons - metabolism Neurons - pathology Original Physics Purkinje Cells - metabolism Purkinje Cells - pathology Rats Rats, Long-Evans Rodents Rotation - adverse effects Traffic accidents & safety
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