Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia

Farnesoid X receptor (FXR) plays important regulatory roles in bile acid, lipoprotein, and glucose homeostasis. Here, we have utilized Fxr−/− mice and mice deficient in scavenger receptor class B type I (SR-BI), together with an FXR-specific agonist and adenovirus expressing hepatocyte nuclear facto...

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Veröffentlicht in:	The Journal of biological chemistry 2010-01, Vol.285 (5), p.3035-3043
Hauptverfasser:	Zhang, Yanqiao, Yin, Liya, Anderson, Jody, Ma, Huiyan, Gonzalez, Frank J., Willson, Timothy M., Edwards, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Animals Bile Acid Cell Line Cholesterol Cholesterol - metabolism Coronary Disease - metabolism FXR Glucose - metabolism Hepatocyte Nuclear Factor 4 - metabolism HNF4α Homeostasis Humans Lipid/Cholesterol Lipoprotein/Receptor Lipoproteins - metabolism Liver - metabolism Metabolism and Bioenergetics Mice Models, Biological Receptors, Cytoplasmic and Nuclear - metabolism Receptors/Nuclear Reverse Cholesterol Transport Scavenger Receptors, Class B - genetics Scavenger Receptors, Class B - metabolism SR-BI
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