Mechanisms involved in the regulation of bovine pulmonary vascular tone by the 5‐HT1B receptor

Background and purpose: 5‐HT1B receptors may have a role in pulmonary hypertension. Their relationship with the activity of BKCa, a T‐type voltage‐operated calcium channel (VOCC) and cyclic nucleotide‐mediated relaxation was examined. Experimental approach: Ring segments of bovine pulmonary arteri...

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Veröffentlicht in:	British journal of pharmacology 2010-01, Vol.159 (1), p.188-200
Hauptverfasser:	McKenzie, C, Alapati, VR, MacDonald, A, Shaw, AM
Format:	Artikel
Sprache:	eng
Schlagworte:	5‐HT1B receptor 5‐hydroxytryptamine Animals Biological and medical sciences BKCa bradykinin Calcium Channels, T-Type - drug effects Calcium Channels, T-Type - metabolism cAMP Cattle cGMP Cyclic AMP - metabolism Cyclic GMP - metabolism Dose-Response Relationship, Drug isoprenaline Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors Large-Conductance Calcium-Activated Potassium Channels - metabolism Medical sciences Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Pharmacology. Drug treatments Pneumology pulmonary arteries Pulmonary Artery - drug effects Pulmonary Artery - metabolism Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Receptor, Serotonin, 5-HT1B - drug effects Receptor, Serotonin, 5-HT1B - metabolism Research Papers Serotonin - administration & dosage Serotonin - pharmacology T‐type voltage‐operated calcium channels
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