Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Nonionic Modifications Better than DNA

DNA and RNA oligonucleotides having formacetal internucleoside linkages between uridine and adenosine nucleosides have been prepared and studied using UV thermal melting, osmotic stress, and X-ray crystallography. Formacetal modifications have remarkably different effects on double helical RNA and D...

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Veröffentlicht in:	Journal of the American Chemical Society 2009-10, Vol.131 (41), p.14932-14937
Hauptverfasser:	Kolarovic, Andrej, Schweizer, Emma, Greene, Emily, Gironda, Mark, Pallan, Pradeep S, Egli, Martin, Rozners, Eriks
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetals - chemistry ADENOSINE Circular Dichroism CRYSTAL STRUCTURE CRYSTALLOGRAPHY Crystallography, X-Ray DNA DNA - chemistry GENES HYDRATION MATERIALS SCIENCE MELTING Models, Molecular MODIFICATIONS national synchrotron light source Nucleic Acid Conformation Nucleic Acid Denaturation NUCLEOSIDES OLIGONUCLEOTIDES Oligonucleotides - chemistry Osmotic Pressure PHOSPHATES RNA RNA - chemistry RNA Stability STABILITY Temperature Transition Temperature URIDINE
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