Synergistic Cooperation between Two ClpB Isoforms in Aggregate Reactivation

Bacterial AAA+ ATPase ClpB cooperates with DnaK during reactivation of aggregated proteins. The ClpB-mediated disaggregation is linked to translocation of polypeptides through the channel in the oligomeric ClpB. Two isoforms of ClpB are produced in vivo: the full-length ClpB95 and ClpB80, which does...

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Veröffentlicht in:	Journal of molecular biology 2010-02, Vol.396 (3), p.697-707
Hauptverfasser:	Nagy, Maria, Guenther, Izabela, Akoyev, Vladimir, Barnett, Micheal E., Zavodszky, Maria I., Kedzierska-Mieszkowska, Sabina, Zolkiewski, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	AAA+ ATPase Adenosine Triphosphate - metabolism ClpB Endopeptidase Clp Escherichia coli - metabolism Escherichia coli - radiation effects Escherichia coli Proteins - metabolism heat shock Heat-Shock Proteins - metabolism Humans Hydrolysis molecular chaperone protein aggregation Protein Isoforms - metabolism Protein Multimerization Protein Renaturation
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