A rev1–vpu polymorphism unique to HIV-1 subtype A and C strains impairs envelope glycoprotein expression from rev–vpu–env cassettes and reduces virion infectivity in pseudotyping assays

Abstract Functional studies of HIV-1 envelope glycoproteins (Envs) commonly include the generation of pseudoviruses, which are produced by co-transfection of rev–vpu–env cassettes with an env -deficient provirus. Here, we describe six Env constructs from transmitted/founder HIV-1 that were defective...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2010-02, Vol.397 (2), p.346-357
Hauptverfasser:	Kraus, Matthias H, Parrish, Nicholas F, Shaw, Katharina S, Decker, Julie M, Keele, Brandon F, Salazar-Gonzalez, Jesus F, Grayson, Truman, McPherson, David T, Ping, Li-Hua, Anderson, Jeffrey A, Swanstrom, Ronald, Williamson, Carolyn, Shaw, George M, Hahn, Beatrice H
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AIDS VIRUS Amino Acid Sequence Base Sequence CARBOHYDRATES Cell Line env Gene Products, Human Immunodeficiency Virus - biosynthesis Env pseudotyping GENES GLYCOPROTEINS HIV-1 - genetics HIV-1 - pathogenicity HIV-1 Env expression HIV-1 gene arrangement HIV-1 subtype A HIV-1 subtype C Human immunodeficiency virus 1 Human Immunodeficiency Virus Proteins - genetics Human Immunodeficiency Virus Proteins - metabolism Humans Infectious Disease INFECTIVITY MICROORGANISMS Molecular Sequence Data ORGANIC COMPOUNDS PARASITES Polymorphism, Genetic Protein Biosynthesis PROTEINS Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism rev Gene Products, Human Immunodeficiency Virus - genetics rev Gene Products, Human Immunodeficiency Virus - metabolism SACCHARIDES STRAINS Viral Regulatory and Accessory Proteins - genetics Viral Regulatory and Accessory Proteins - metabolism VIRUSES
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