Psychopharmacological effects of oxycodone in healthy volunteers: Roles of alcohol-drinking status and sex
Abstract Background Studies have shown that alcohol-drinking status modulates psychopharmacological effects of several drugs. We sought to determine if drinking status modulates the effects of a prescription opioid, oxycodone, in healthy volunteers. We included sex of the volunteer in the statistica...
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| description | Abstract Background Studies have shown that alcohol-drinking status modulates psychopharmacological effects of several drugs. We sought to determine if drinking status modulates the effects of a prescription opioid, oxycodone, in healthy volunteers. We included sex of the volunteer in the statistical analyses since this is a factor that is known to alter several pharmacodynamic effects of opioids in nonhumans and humans. Methods Fifteen light drinkers (eight males) and 14 moderate drinkers (eight males) participated in a crossover, randomized, double-blind study in which they received 0, 10, and 20 mg of oxycodone (p.o.). Dependent measures were subjective, psychomotor/cognitive, reinforcing, and physiological effects. Results Self-reported alcohol-drinking status did not modulate the effects of oxycodone. However, there were a number of Sex × Dose interactions with females reporting more and larger unpleasant effects than males (e.g., visual analog scale ratings of “nauseated” greater in females than in males). Conclusions Studies have established that moderate drinkers report a greater degree of abuse liability-related effects than do light drinkers with several different drugs, including diazepam, amphetamine, and nitrous oxide, but we were unable to establish this with the prescription opioid, oxycodone. However, we did observe sex differences in several subjective effects of oxycodone, a finding that is consistent with the extant literature showing sex differences in pharmacodynamic effects of opioids. |
| doi_str_mv | 10.1016/j.drugalcdep.2009.10.012 |
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We sought to determine if drinking status modulates the effects of a prescription opioid, oxycodone, in healthy volunteers. We included sex of the volunteer in the statistical analyses since this is a factor that is known to alter several pharmacodynamic effects of opioids in nonhumans and humans. Methods Fifteen light drinkers (eight males) and 14 moderate drinkers (eight males) participated in a crossover, randomized, double-blind study in which they received 0, 10, and 20 mg of oxycodone (p.o.). Dependent measures were subjective, psychomotor/cognitive, reinforcing, and physiological effects. Results Self-reported alcohol-drinking status did not modulate the effects of oxycodone. However, there were a number of Sex × Dose interactions with females reporting more and larger unpleasant effects than males (e.g., visual analog scale ratings of “nauseated” greater in females than in males). Conclusions Studies have established that moderate drinkers report a greater degree of abuse liability-related effects than do light drinkers with several different drugs, including diazepam, amphetamine, and nitrous oxide, but we were unable to establish this with the prescription opioid, oxycodone. However, we did observe sex differences in several subjective effects of oxycodone, a finding that is consistent with the extant literature showing sex differences in pharmacodynamic effects of opioids.</description><identifier>ISSN: 0376-8716</identifier><identifier>EISSN: 1879-0046</identifier><identifier>DOI: 10.1016/j.drugalcdep.2009.10.012</identifier><identifier>PMID: 19948383</identifier><identifier>CODEN: DADEDV</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Addictive behaviors ; Adult ; Adult and adolescent clinical studies ; Alcohol ; Alcohol Drinking - psychology ; Amphetamine ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - adverse effects ; Analgesics, Opioid - pharmacology ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Drug addiction ; Drug Interactions ; Ethanol - pharmacology ; Female ; Gender ; Gender differences ; Human ; Humans ; Male ; Medical sciences ; Men ; Multiple-Choice Procedure ; Nausea - chemically induced ; Opioid ; Opioids ; Oxycodone ; Oxycodone - administration & dosage ; Oxycodone - adverse effects ; Oxycodone - pharmacology ; Prescription ; Prescriptions ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor ; Psychomotor Performance - drug effects ; Psychopathology. Psychiatry ; Psychopharmacology ; Reinforcement (Psychology) ; Sex Characteristics ; Sex differences ; Sex Factors ; Subjective effects ; Substance-Related Disorders - psychology ; Volunteers</subject><ispartof>Drug and alcohol dependence, 2010-03, Vol.107 (2), p.209-214</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2009 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c626t-edb69a47f39347cdd7c2130af9583dad72935798c16175cffa27119d4bb598e53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0376871609004025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,30977,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22514266$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19948383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zacny, James P</creatorcontrib><creatorcontrib>Drum, Melinda</creatorcontrib><title>Psychopharmacological effects of oxycodone in healthy volunteers: Roles of alcohol-drinking status and sex</title><title>Drug and alcohol dependence</title><addtitle>Drug Alcohol Depend</addtitle><description>Abstract Background Studies have shown that alcohol-drinking status modulates psychopharmacological effects of several drugs. We sought to determine if drinking status modulates the effects of a prescription opioid, oxycodone, in healthy volunteers. We included sex of the volunteer in the statistical analyses since this is a factor that is known to alter several pharmacodynamic effects of opioids in nonhumans and humans. Methods Fifteen light drinkers (eight males) and 14 moderate drinkers (eight males) participated in a crossover, randomized, double-blind study in which they received 0, 10, and 20 mg of oxycodone (p.o.). Dependent measures were subjective, psychomotor/cognitive, reinforcing, and physiological effects. Results Self-reported alcohol-drinking status did not modulate the effects of oxycodone. However, there were a number of Sex × Dose interactions with females reporting more and larger unpleasant effects than males (e.g., visual analog scale ratings of “nauseated” greater in females than in males). Conclusions Studies have established that moderate drinkers report a greater degree of abuse liability-related effects than do light drinkers with several different drugs, including diazepam, amphetamine, and nitrous oxide, but we were unable to establish this with the prescription opioid, oxycodone. However, we did observe sex differences in several subjective effects of oxycodone, a finding that is consistent with the extant literature showing sex differences in pharmacodynamic effects of opioids.</description><subject>Addictive behaviors</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Alcohol</subject><subject>Alcohol Drinking - psychology</subject><subject>Amphetamine</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug addiction</subject><subject>Drug Interactions</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Gender</subject><subject>Gender differences</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Men</subject><subject>Multiple-Choice Procedure</subject><subject>Nausea - chemically induced</subject><subject>Opioid</subject><subject>Opioids</subject><subject>Oxycodone</subject><subject>Oxycodone - administration & dosage</subject><subject>Oxycodone - adverse effects</subject><subject>Oxycodone - pharmacology</subject><subject>Prescription</subject><subject>Prescriptions</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor</subject><subject>Psychomotor Performance - drug effects</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Reinforcement (Psychology)</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Subjective effects</subject><subject>Substance-Related Disorders - psychology</subject><subject>Volunteers</subject><issn>0376-8716</issn><issn>1879-0046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkkuPFCEQgInRuOvoXzB9UU898uiGxsMmuvGVbKLxcSYMVE8zy8AI3ZOdfy_tTHbVg5ELCfVRVfAVQhXBS4IJf7lZ2jSttTcWdkuKsSzHS0zoPXROOiFrjBt-H51jJnjdCcLP0KOcN7gsLvFDdEakbDrWsXO0-ZwPZoi7QaetNtHHtTPaV9D3YMZcxb6KNwcTbQxQuVANoP04HKp99FMYAVJ-VX2JHn6RpZ84RF_b5MK1C-sqj3qccqWDrTLcPEYPeu0zPDntC_T93dtvlx_qq0_vP16-vqoNp3yswa641I3omWSNMNYKQwnDupdtx6y2gkrWCtkZwoloTd9rKgiRtlmtWtlByxbo4ph3N622YA2EMWmvdsltdTqoqJ36MxLcoNZxr2hHKS5VF-jFKUGKPybIo9q6bMB7HSBOWYmGY9x27Vzq-T_JVrBGSkEL2B1Bk2LOCfrbdghWs1K1UXdK1ax0jhSl5erT359zd_HksADPToDOxV2fdDAu33KUtqShnBfuzZGD8vl7B0ll4yAYsC4V2cpG9z_dXPyVxHgX5pm5hgPkTZxSKHIVUZkqrL7OIzhPIJZlJjFt2U9Xk9xt</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Zacny, James P</creator><creator>Drum, Melinda</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20100301</creationdate><title>Psychopharmacological effects of oxycodone in healthy volunteers: Roles of alcohol-drinking status and sex</title><author>Zacny, James P ; Drum, Melinda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c626t-edb69a47f39347cdd7c2130af9583dad72935798c16175cffa27119d4bb598e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Addictive behaviors</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Alcohol</topic><topic>Alcohol Drinking - psychology</topic><topic>Amphetamine</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug addiction</topic><topic>Drug Interactions</topic><topic>Ethanol - pharmacology</topic><topic>Female</topic><topic>Gender</topic><topic>Gender differences</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Men</topic><topic>Multiple-Choice Procedure</topic><topic>Nausea - chemically induced</topic><topic>Opioid</topic><topic>Opioids</topic><topic>Oxycodone</topic><topic>Oxycodone - administration & dosage</topic><topic>Oxycodone - adverse effects</topic><topic>Oxycodone - pharmacology</topic><topic>Prescription</topic><topic>Prescriptions</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor</topic><topic>Psychomotor Performance - drug effects</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Reinforcement (Psychology)</topic><topic>Sex Characteristics</topic><topic>Sex differences</topic><topic>Sex Factors</topic><topic>Subjective effects</topic><topic>Substance-Related Disorders - psychology</topic><topic>Volunteers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zacny, James P</creatorcontrib><creatorcontrib>Drum, Melinda</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Drug and alcohol dependence</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zacny, James P</au><au>Drum, Melinda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychopharmacological effects of oxycodone in healthy volunteers: Roles of alcohol-drinking status and sex</atitle><jtitle>Drug and alcohol dependence</jtitle><addtitle>Drug Alcohol Depend</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>107</volume><issue>2</issue><spage>209</spage><epage>214</epage><pages>209-214</pages><issn>0376-8716</issn><eissn>1879-0046</eissn><coden>DADEDV</coden><abstract>Abstract Background Studies have shown that alcohol-drinking status modulates psychopharmacological effects of several drugs. We sought to determine if drinking status modulates the effects of a prescription opioid, oxycodone, in healthy volunteers. We included sex of the volunteer in the statistical analyses since this is a factor that is known to alter several pharmacodynamic effects of opioids in nonhumans and humans. Methods Fifteen light drinkers (eight males) and 14 moderate drinkers (eight males) participated in a crossover, randomized, double-blind study in which they received 0, 10, and 20 mg of oxycodone (p.o.). Dependent measures were subjective, psychomotor/cognitive, reinforcing, and physiological effects. Results Self-reported alcohol-drinking status did not modulate the effects of oxycodone. However, there were a number of Sex × Dose interactions with females reporting more and larger unpleasant effects than males (e.g., visual analog scale ratings of “nauseated” greater in females than in males). Conclusions Studies have established that moderate drinkers report a greater degree of abuse liability-related effects than do light drinkers with several different drugs, including diazepam, amphetamine, and nitrous oxide, but we were unable to establish this with the prescription opioid, oxycodone. However, we did observe sex differences in several subjective effects of oxycodone, a finding that is consistent with the extant literature showing sex differences in pharmacodynamic effects of opioids.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19948383</pmid><doi>10.1016/j.drugalcdep.2009.10.012</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Addictive behaviors Adult Adult and adolescent clinical studies Alcohol Alcohol Drinking - psychology Amphetamine Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Analgesics, Opioid - pharmacology Biological and medical sciences Dose-Response Relationship, Drug Drug addiction Drug Interactions Ethanol - pharmacology Female Gender Gender differences Human Humans Male Medical sciences Men Multiple-Choice Procedure Nausea - chemically induced Opioid Opioids Oxycodone Oxycodone - administration & dosage Oxycodone - adverse effects Oxycodone - pharmacology Prescription Prescriptions Psychiatry Psychology. Psychoanalysis. Psychiatry Psychomotor Psychomotor Performance - drug effects Psychopathology. Psychiatry Psychopharmacology Reinforcement (Psychology) Sex Characteristics Sex differences Sex Factors Subjective effects Substance-Related Disorders - psychology Volunteers |
| title | Psychopharmacological effects of oxycodone in healthy volunteers: Roles of alcohol-drinking status and sex |
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