Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia

Abstract The excitatory amino acid transporters (EAATs) are a family of molecules that are essential for regulation of synaptic glutamate levels. The EAATs may also be regulated by N-glycosylation, a posttranslational modification that is critical for many cellular functions including localization i...

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Veröffentlicht in:	Schizophrenia research 2010-03, Vol.117 (1), p.92-98
Hauptverfasser:	Bauer, Deborah, Haroutunian, Vahram, Meador-Woodruff, James H, McCullumsmith, Robert E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Aged Anterior cingulate cortex Biological and medical sciences Blotting, Western Brain - pathology Deglycosylation Dorsolateral prefrontal cortex EAAC1 Excitatory Amino Acid Transporter 1 - genetics Excitatory Amino Acid Transporter 1 - metabolism Female GLAST GLT-1 Glutamate Plasma Membrane Transport Proteins - genetics Glutamate Plasma Membrane Transport Proteins - metabolism Glycosylation Humans Male Medical sciences Prefrontal Cortex - metabolism Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - genetics Schizophrenia - metabolism Schizophrenia - pathology
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