Evolution of MRSA During Hospital Transmission and Intercontinental Spread
Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2010-01, Vol.327 (5964), p.469-474 |
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| creator | Harris, Simon R Feil, Edward J Holden, Matthew T.G Quail, Michael A Nickerson, Emma K Chantratita, Narisara Gardete, Susana Tavares, Ana Day, Nick Lindsay, Jodi A Edgeworth, Jonathan D de Lencastre, Hermínia Parkhill, Julian Peacock, Sharon J Bentley, Stephen D |
| description | Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology. |
| doi_str_mv | 10.1126/science.1182395 |
| format | Article |
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Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1182395</identifier><identifier>PMID: 20093474</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Asia - epidemiology ; Bacterial Typing Techniques ; Bacteriology ; Biological and medical sciences ; Carrier proteins ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Cross Infection - transmission ; Data transmission ; Disease transmission ; Epidemiology ; Europe - epidemiology ; Evolution ; Evolution, Molecular ; Fundamental and applied biological sciences. Psychology ; Genetic mutation ; Genome, Bacterial ; Genomes ; Genomics ; Genomics - methods ; Humans ; Likelihood Functions ; Methicillin-Resistant Staphylococcus aureus - classification ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Microbiology ; Molecular Epidemiology ; Molecular Sequence Data ; Nosocomial infections ; Pathogens ; Phylogenetics ; Phylogeny ; Polymorphism, Single Nucleotide ; Sequence Analysis, DNA ; Sequencing ; South America - epidemiology ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - microbiology ; Staphylococcal Infections - transmission ; Staphylococcus aureus ; Staphylococcus infections ; Time Factors ; United States - epidemiology</subject><ispartof>Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5964), p.469-474</ispartof><rights>Copyright 2010 American Association for the Advancement of Science</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010, American Association for the Advancement of Science</rights><rights>Copyright 2010 by the American Association for the Advancement of Science; all rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-84ec5a094591401dfd2877589afb4688561263af39abde1a94be072d76cae6f13</citedby><cites>FETCH-LOGICAL-c653t-84ec5a094591401dfd2877589afb4688561263af39abde1a94be072d76cae6f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40508601$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40508601$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,776,780,799,881,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22331965$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20093474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harris, Simon R</creatorcontrib><creatorcontrib>Feil, Edward J</creatorcontrib><creatorcontrib>Holden, Matthew T.G</creatorcontrib><creatorcontrib>Quail, Michael A</creatorcontrib><creatorcontrib>Nickerson, Emma K</creatorcontrib><creatorcontrib>Chantratita, Narisara</creatorcontrib><creatorcontrib>Gardete, Susana</creatorcontrib><creatorcontrib>Tavares, Ana</creatorcontrib><creatorcontrib>Day, Nick</creatorcontrib><creatorcontrib>Lindsay, Jodi A</creatorcontrib><creatorcontrib>Edgeworth, Jonathan D</creatorcontrib><creatorcontrib>de Lencastre, Hermínia</creatorcontrib><creatorcontrib>Parkhill, Julian</creatorcontrib><creatorcontrib>Peacock, Sharon J</creatorcontrib><creatorcontrib>Bentley, Stephen D</creatorcontrib><title>Evolution of MRSA During Hospital Transmission and Intercontinental Spread</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.</description><subject>Asia - epidemiology</subject><subject>Bacterial Typing Techniques</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Carrier proteins</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - microbiology</subject><subject>Cross Infection - transmission</subject><subject>Data transmission</subject><subject>Disease transmission</subject><subject>Epidemiology</subject><subject>Europe - epidemiology</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic mutation</subject><subject>Genome, Bacterial</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Genomics - methods</subject><subject>Humans</subject><subject>Likelihood Functions</subject><subject>Methicillin-Resistant Staphylococcus aureus - classification</subject><subject>Methicillin-Resistant Staphylococcus aureus - genetics</subject><subject>Methicillin-Resistant Staphylococcus aureus - isolation & purification</subject><subject>Microbiology</subject><subject>Molecular Epidemiology</subject><subject>Molecular Sequence Data</subject><subject>Nosocomial infections</subject><subject>Pathogens</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Sequence Analysis, DNA</subject><subject>Sequencing</subject><subject>South America - epidemiology</subject><subject>Staphylococcal Infections - epidemiology</subject><subject>Staphylococcal Infections - microbiology</subject><subject>Staphylococcal Infections - transmission</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Time Factors</subject><subject>United States - epidemiology</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtvEzEUhS0EoqGwZgWMkIDVUL8fG6SqFFpUhETateV47OBoYqf2TCX-PR5lCI8FrGzrfD665x4AniL4FiHMT4oNLlpXHxITxe6BBYKKtQpDch8sICS8lVCwI_ColA2EVVPkITjC9UaooAvw6fwu9eMQUmySbz5_XZ4278cc4rq5SGUXBtM319nEsg2lTJCJXXMZB5dtikOILk7Ecped6R6DB970xT2Zz2Nw8-H8-uyivfry8fLs9Kq1nJGhldRZZqCiTCEKUec7LIVgUhm_olxKxmswYjxRZtU5ZBRdOShwJ7g1jntEjsG7ve9uXG1dZ-sM2fR6l8PW5O86maD_VGL4ptfpTmOJEVewGryZDXK6HV0ZdE1nXd-b6NJYtCAUQqkYr-Trf5KEU0Kq7X9BjAgiDIsKvvwL3KQxx7qviWFKCMkqdLKHbE6lZOcP4RDUU-967l3Pvdcfz3_fyYH_WXQFXs2AKdb0vnZqQ_nFYUKQ4pPRsz23KUPKB51CBiWH0_Jf7HVvkjbrXD1ulrgKEAlFcW3uB3bxyZM</recordid><startdate>20100122</startdate><enddate>20100122</enddate><creator>Harris, Simon R</creator><creator>Feil, Edward J</creator><creator>Holden, Matthew T.G</creator><creator>Quail, Michael A</creator><creator>Nickerson, Emma K</creator><creator>Chantratita, Narisara</creator><creator>Gardete, Susana</creator><creator>Tavares, Ana</creator><creator>Day, Nick</creator><creator>Lindsay, Jodi A</creator><creator>Edgeworth, Jonathan D</creator><creator>de Lencastre, Hermínia</creator><creator>Parkhill, Julian</creator><creator>Peacock, Sharon J</creator><creator>Bentley, Stephen D</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100122</creationdate><title>Evolution of MRSA During Hospital Transmission and Intercontinental Spread</title><author>Harris, Simon R ; Feil, Edward J ; Holden, Matthew T.G ; Quail, Michael A ; Nickerson, Emma K ; Chantratita, Narisara ; Gardete, Susana ; Tavares, Ana ; Day, Nick ; Lindsay, Jodi A ; Edgeworth, Jonathan D ; de Lencastre, Hermínia ; Parkhill, Julian ; Peacock, Sharon J ; Bentley, Stephen D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-84ec5a094591401dfd2877589afb4688561263af39abde1a94be072d76cae6f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Asia - epidemiology</topic><topic>Bacterial Typing Techniques</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Carrier proteins</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - microbiology</topic><topic>Cross Infection - transmission</topic><topic>Data transmission</topic><topic>Disease transmission</topic><topic>Epidemiology</topic><topic>Europe - epidemiology</topic><topic>Evolution</topic><topic>Evolution, Molecular</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic mutation</topic><topic>Genome, Bacterial</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Genomics - methods</topic><topic>Humans</topic><topic>Likelihood Functions</topic><topic>Methicillin-Resistant Staphylococcus aureus - classification</topic><topic>Methicillin-Resistant Staphylococcus aureus - genetics</topic><topic>Methicillin-Resistant Staphylococcus aureus - isolation & purification</topic><topic>Microbiology</topic><topic>Molecular Epidemiology</topic><topic>Molecular Sequence Data</topic><topic>Nosocomial infections</topic><topic>Pathogens</topic><topic>Phylogenetics</topic><topic>Phylogeny</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Sequence Analysis, DNA</topic><topic>Sequencing</topic><topic>South America - epidemiology</topic><topic>Staphylococcal Infections - epidemiology</topic><topic>Staphylococcal Infections - microbiology</topic><topic>Staphylococcal Infections - transmission</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus infections</topic><topic>Time Factors</topic><topic>United States - 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Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>20093474</pmid><doi>10.1126/science.1182395</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5964), p.469-474 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2821690 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Asia - epidemiology Bacterial Typing Techniques Bacteriology Biological and medical sciences Carrier proteins Cross Infection - epidemiology Cross Infection - microbiology Cross Infection - transmission Data transmission Disease transmission Epidemiology Europe - epidemiology Evolution Evolution, Molecular Fundamental and applied biological sciences. Psychology Genetic mutation Genome, Bacterial Genomes Genomics Genomics - methods Humans Likelihood Functions Methicillin-Resistant Staphylococcus aureus - classification Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - isolation & purification Microbiology Molecular Epidemiology Molecular Sequence Data Nosocomial infections Pathogens Phylogenetics Phylogeny Polymorphism, Single Nucleotide Sequence Analysis, DNA Sequencing South America - epidemiology Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcal Infections - transmission Staphylococcus aureus Staphylococcus infections Time Factors United States - epidemiology |
| title | Evolution of MRSA During Hospital Transmission and Intercontinental Spread |
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