Short Report : Childhood Coinfections with Plasmodium falciparum and Schistosoma mansoni Result in Lower Percentages of Activated T Cells and T Regulatory Memory Cells than Schistosomiasis Only
Flow cytometric analyses were performed to evaluate HLA-DR (+) activated T lymphocytes (Tact; CD3 (+)/CD4 (+)/CD25(medium)) and T regulatory cells (Treg; CD3 (+)/CD4(+)/CD25(high)) in the circulation of children 8-10 years of age living in an area endemic for both Plasmodium falciparum and Schistoso...
Gespeichert in:
| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2009-03, Vol.80 (3), p.475-478 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 478 |
|---|---|
| container_issue | 3 |
| container_start_page | 475 |
| container_title | The American journal of tropical medicine and hygiene |
| container_volume | 80 |
| creator | MOUK, Erick M. O MWINZI, Pauline N. M BLACK, Carla L CARTER, Jennifer M NG'ANG'A, Zipporah W GICHERU, Michael M SECOR, W. Evan KARANJA, Diana M. S COLLEY, Daniel G |
| description | Flow cytometric analyses were performed to evaluate HLA-DR (+) activated T lymphocytes (Tact; CD3 (+)/CD4 (+)/CD25(medium)) and T regulatory cells (Treg; CD3 (+)/CD4(+)/CD25(high)) in the circulation of children 8-10 years of age living in an area endemic for both Plasmodium falciparum and Schistosoma mansoni in western Kenya. Those children with only S. mansoni had a higher mean percentage of HLA-DR (+) Tact than those who were co-infected with these two intravascular parasites. The proportion of circulating Treg was comparable in children with only schistosomiasis and both schistosomiasis and malaria. However, the mean level of memory Treg (Treg expressing CD45RO (+)) in those with dual infections was lower than in children with schistosomiasis alone. These imbalances in Tact and Treg memory subsets in children infected with both schistosomiasis and malaria may be related to the differential morbidity or course of infection attributed to coinfections with these parasites. |
| doi_str_mv | 10.4269/ajtmh.2009.80.475 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2821587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67007080</sourcerecordid><originalsourceid>FETCH-LOGICAL-p294t-3d32c97db3036bc062736cf62f2daea156149790bc09f6698e2c9d552d76b61d3</originalsourceid><addsrcrecordid>eNpVkc1u1DAUhS0EokPhAdggb2CXwT-JnbBAqiL-pEGt6LCO7tjOxJVjh9hpNY_Hm-GhQ1VWx_I5_o6vjdBrStYlE817uEnjsGaENOs6b8nqCVrRUoqCirJ6ilaEEFY0gssz9CLGG0JozSh9js5owyThhK7Q7-shzAn_MNNRPuB2sE4PIWjcBut7o5INPuI7mwZ85SCOQdtlxD04ZSeY8xK8xtdqsDGFGEbAI_gYvM3IuLiErcebcGdmfGVmZXyCvYk49Pgik28hGY23uDXOxb-gbT62XxykMB_wdzMe5d5NA_hHPRaijfjSu8NL9CzfJppXJz1HPz9_2rZfi83ll2_txaaYWFOmgmvOVCP1jhMudooIJrlQvWA902CAVoKWjWxItppeiKY2Oa6rimkpdoJqfo4-3nOnZTcafZxlBtdNsx1hPnQBbPe_4-3Q7cNtx_KjV7XMgHcnwBx-LSambrRR5eHAm7DETkhCJKlJDr553PRQ8e_XcuDtKQBRgetn8MrGhxyjrOKsLPkfTvis1Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67007080</pqid></control><display><type>article</type><title>Short Report : Childhood Coinfections with Plasmodium falciparum and Schistosoma mansoni Result in Lower Percentages of Activated T Cells and T Regulatory Memory Cells than Schistosomiasis Only</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>MOUK, Erick M. O ; MWINZI, Pauline N. M ; BLACK, Carla L ; CARTER, Jennifer M ; NG'ANG'A, Zipporah W ; GICHERU, Michael M ; SECOR, W. Evan ; KARANJA, Diana M. S ; COLLEY, Daniel G</creator><creatorcontrib>MOUK, Erick M. O ; MWINZI, Pauline N. M ; BLACK, Carla L ; CARTER, Jennifer M ; NG'ANG'A, Zipporah W ; GICHERU, Michael M ; SECOR, W. Evan ; KARANJA, Diana M. S ; COLLEY, Daniel G</creatorcontrib><description>Flow cytometric analyses were performed to evaluate HLA-DR (+) activated T lymphocytes (Tact; CD3 (+)/CD4 (+)/CD25(medium)) and T regulatory cells (Treg; CD3 (+)/CD4(+)/CD25(high)) in the circulation of children 8-10 years of age living in an area endemic for both Plasmodium falciparum and Schistosoma mansoni in western Kenya. Those children with only S. mansoni had a higher mean percentage of HLA-DR (+) Tact than those who were co-infected with these two intravascular parasites. The proportion of circulating Treg was comparable in children with only schistosomiasis and both schistosomiasis and malaria. However, the mean level of memory Treg (Treg expressing CD45RO (+)) in those with dual infections was lower than in children with schistosomiasis alone. These imbalances in Tact and Treg memory subsets in children infected with both schistosomiasis and malaria may be related to the differential morbidity or course of infection attributed to coinfections with these parasites.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.2009.80.475</identifier><identifier>PMID: 19270301</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Deerfield, IL: American Society of Tropical Medecine and Hygiene</publisher><subject>Animals ; Biological and medical sciences ; Child ; Diseases caused by trematodes ; Female ; Flow Cytometry ; Helminthic diseases ; Humans ; Infectious diseases ; Malaria, Falciparum - complications ; Malaria, Falciparum - immunology ; Male ; Medical sciences ; Parasitic diseases ; Plasmodium falciparum - immunology ; Schistosoma mansoni - immunology ; Schistosomiases ; Schistosomiasis mansoni - complications ; Schistosomiasis mansoni - immunology ; T-Lymphocyte Subsets - physiology</subject><ispartof>The American journal of tropical medicine and hygiene, 2009-03, Vol.80 (3), p.475-478</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright © 2009 by The American Society of Tropical Medicine and Hygiene 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21253244$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19270301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOUK, Erick M. O</creatorcontrib><creatorcontrib>MWINZI, Pauline N. M</creatorcontrib><creatorcontrib>BLACK, Carla L</creatorcontrib><creatorcontrib>CARTER, Jennifer M</creatorcontrib><creatorcontrib>NG'ANG'A, Zipporah W</creatorcontrib><creatorcontrib>GICHERU, Michael M</creatorcontrib><creatorcontrib>SECOR, W. Evan</creatorcontrib><creatorcontrib>KARANJA, Diana M. S</creatorcontrib><creatorcontrib>COLLEY, Daniel G</creatorcontrib><title>Short Report : Childhood Coinfections with Plasmodium falciparum and Schistosoma mansoni Result in Lower Percentages of Activated T Cells and T Regulatory Memory Cells than Schistosomiasis Only</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>Flow cytometric analyses were performed to evaluate HLA-DR (+) activated T lymphocytes (Tact; CD3 (+)/CD4 (+)/CD25(medium)) and T regulatory cells (Treg; CD3 (+)/CD4(+)/CD25(high)) in the circulation of children 8-10 years of age living in an area endemic for both Plasmodium falciparum and Schistosoma mansoni in western Kenya. Those children with only S. mansoni had a higher mean percentage of HLA-DR (+) Tact than those who were co-infected with these two intravascular parasites. The proportion of circulating Treg was comparable in children with only schistosomiasis and both schistosomiasis and malaria. However, the mean level of memory Treg (Treg expressing CD45RO (+)) in those with dual infections was lower than in children with schistosomiasis alone. These imbalances in Tact and Treg memory subsets in children infected with both schistosomiasis and malaria may be related to the differential morbidity or course of infection attributed to coinfections with these parasites.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Diseases caused by trematodes</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Helminthic diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaria, Falciparum - complications</subject><subject>Malaria, Falciparum - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum - immunology</subject><subject>Schistosoma mansoni - immunology</subject><subject>Schistosomiases</subject><subject>Schistosomiasis mansoni - complications</subject><subject>Schistosomiasis mansoni - immunology</subject><subject>T-Lymphocyte Subsets - physiology</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1u1DAUhS0EokPhAdggb2CXwT-JnbBAqiL-pEGt6LCO7tjOxJVjh9hpNY_Hm-GhQ1VWx_I5_o6vjdBrStYlE817uEnjsGaENOs6b8nqCVrRUoqCirJ6ilaEEFY0gssz9CLGG0JozSh9js5owyThhK7Q7-shzAn_MNNRPuB2sE4PIWjcBut7o5INPuI7mwZ85SCOQdtlxD04ZSeY8xK8xtdqsDGFGEbAI_gYvM3IuLiErcebcGdmfGVmZXyCvYk49Pgik28hGY23uDXOxb-gbT62XxykMB_wdzMe5d5NA_hHPRaijfjSu8NL9CzfJppXJz1HPz9_2rZfi83ll2_txaaYWFOmgmvOVCP1jhMudooIJrlQvWA902CAVoKWjWxItppeiKY2Oa6rimkpdoJqfo4-3nOnZTcafZxlBtdNsx1hPnQBbPe_4-3Q7cNtx_KjV7XMgHcnwBx-LSambrRR5eHAm7DETkhCJKlJDr553PRQ8e_XcuDtKQBRgetn8MrGhxyjrOKsLPkfTvis1Q</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>MOUK, Erick M. O</creator><creator>MWINZI, Pauline N. M</creator><creator>BLACK, Carla L</creator><creator>CARTER, Jennifer M</creator><creator>NG'ANG'A, Zipporah W</creator><creator>GICHERU, Michael M</creator><creator>SECOR, W. Evan</creator><creator>KARANJA, Diana M. S</creator><creator>COLLEY, Daniel G</creator><general>American Society of Tropical Medecine and Hygiene</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090301</creationdate><title>Short Report : Childhood Coinfections with Plasmodium falciparum and Schistosoma mansoni Result in Lower Percentages of Activated T Cells and T Regulatory Memory Cells than Schistosomiasis Only</title><author>MOUK, Erick M. O ; MWINZI, Pauline N. M ; BLACK, Carla L ; CARTER, Jennifer M ; NG'ANG'A, Zipporah W ; GICHERU, Michael M ; SECOR, W. Evan ; KARANJA, Diana M. S ; COLLEY, Daniel G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p294t-3d32c97db3036bc062736cf62f2daea156149790bc09f6698e2c9d552d76b61d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Diseases caused by trematodes</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Helminthic diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaria, Falciparum - complications</topic><topic>Malaria, Falciparum - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum - immunology</topic><topic>Schistosoma mansoni - immunology</topic><topic>Schistosomiases</topic><topic>Schistosomiasis mansoni - complications</topic><topic>Schistosomiasis mansoni - immunology</topic><topic>T-Lymphocyte Subsets - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOUK, Erick M. O</creatorcontrib><creatorcontrib>MWINZI, Pauline N. M</creatorcontrib><creatorcontrib>BLACK, Carla L</creatorcontrib><creatorcontrib>CARTER, Jennifer M</creatorcontrib><creatorcontrib>NG'ANG'A, Zipporah W</creatorcontrib><creatorcontrib>GICHERU, Michael M</creatorcontrib><creatorcontrib>SECOR, W. Evan</creatorcontrib><creatorcontrib>KARANJA, Diana M. S</creatorcontrib><creatorcontrib>COLLEY, Daniel G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOUK, Erick M. O</au><au>MWINZI, Pauline N. M</au><au>BLACK, Carla L</au><au>CARTER, Jennifer M</au><au>NG'ANG'A, Zipporah W</au><au>GICHERU, Michael M</au><au>SECOR, W. Evan</au><au>KARANJA, Diana M. S</au><au>COLLEY, Daniel G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short Report : Childhood Coinfections with Plasmodium falciparum and Schistosoma mansoni Result in Lower Percentages of Activated T Cells and T Regulatory Memory Cells than Schistosomiasis Only</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>80</volume><issue>3</issue><spage>475</spage><epage>478</epage><pages>475-478</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>Flow cytometric analyses were performed to evaluate HLA-DR (+) activated T lymphocytes (Tact; CD3 (+)/CD4 (+)/CD25(medium)) and T regulatory cells (Treg; CD3 (+)/CD4(+)/CD25(high)) in the circulation of children 8-10 years of age living in an area endemic for both Plasmodium falciparum and Schistosoma mansoni in western Kenya. Those children with only S. mansoni had a higher mean percentage of HLA-DR (+) Tact than those who were co-infected with these two intravascular parasites. The proportion of circulating Treg was comparable in children with only schistosomiasis and both schistosomiasis and malaria. However, the mean level of memory Treg (Treg expressing CD45RO (+)) in those with dual infections was lower than in children with schistosomiasis alone. These imbalances in Tact and Treg memory subsets in children infected with both schistosomiasis and malaria may be related to the differential morbidity or course of infection attributed to coinfections with these parasites.</abstract><cop>Deerfield, IL</cop><pub>American Society of Tropical Medecine and Hygiene</pub><pmid>19270301</pmid><doi>10.4269/ajtmh.2009.80.475</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9637 |
| ispartof | The American journal of tropical medicine and hygiene, 2009-03, Vol.80 (3), p.475-478 |
| issn | 0002-9637 1476-1645 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2821587 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Child Diseases caused by trematodes Female Flow Cytometry Helminthic diseases Humans Infectious diseases Malaria, Falciparum - complications Malaria, Falciparum - immunology Male Medical sciences Parasitic diseases Plasmodium falciparum - immunology Schistosoma mansoni - immunology Schistosomiases Schistosomiasis mansoni - complications Schistosomiasis mansoni - immunology T-Lymphocyte Subsets - physiology |
| title | Short Report : Childhood Coinfections with Plasmodium falciparum and Schistosoma mansoni Result in Lower Percentages of Activated T Cells and T Regulatory Memory Cells than Schistosomiasis Only |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T17%3A39%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Short%20Report%20:%20Childhood%20Coinfections%20with%20Plasmodium%20falciparum%20and%20Schistosoma%20mansoni%20Result%20in%20Lower%20Percentages%20of%20Activated%20T%20Cells%20and%20T%20Regulatory%20Memory%20Cells%20than%20Schistosomiasis%20Only&rft.jtitle=The%20American%20journal%20of%20tropical%20medicine%20and%20hygiene&rft.au=MOUK,%20Erick%20M.%20O&rft.date=2009-03-01&rft.volume=80&rft.issue=3&rft.spage=475&rft.epage=478&rft.pages=475-478&rft.issn=0002-9637&rft.eissn=1476-1645&rft.coden=AJTHAB&rft_id=info:doi/10.4269/ajtmh.2009.80.475&rft_dat=%3Cproquest_pubme%3E67007080%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67007080&rft_id=info:pmid/19270301&rfr_iscdi=true |