Soluble P-Selectin and the Risk of Primary Graft Dysfunction After Lung Transplantation
Background: Platelet activation with subsequent neutrophilic adherence to the vasculature initiates ischemia-reperfusion injury. We hypothesized that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction (PGD) after lung transplan...
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| Veröffentlicht in: | Chest 2009-07, Vol.136 (1), p.237-244 |
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| creator | KAWUT, Steven M OKUN, Jeffrey DEMISSIE, Ejigayehu CHRISTIE, Jason D SHIMBO, Daichi LEDERER, David J DE ANDRADE, Joao LAMA, Vibha SHAH, Ashish MILSTONE, Aaron WARE, Lorraine B WEINACKER, Ann |
| description | Background: Platelet activation with subsequent neutrophilic adherence to the vasculature initiates ischemia-reperfusion injury. We hypothesized
that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction
(PGD) after lung transplantation.
Methods: In a prospective, multicenter cohort study of 376 patients who had undergone lung transplantation between 2002 and 2007,
we measured soluble P-selectin levels before lung transplantation and at 6 and 24 h after lung reperfusion in 20 patients
with grade III PGD (Pa o 2 /fraction of inspired oxygen, < 200 mm Hg [with alveolar infiltrates seen on chest radiographs]) at 72 h after transplantation
and 61 control subjects without PGD.
Results: Higher postoperative soluble P-selectin levels were associated with an increased risk of PGD at 72 h after transplantation
(odds ratio [OR] per 1 natural log increase in soluble P-selectin at 6 h after lung allograft reperfusion, 3.5; 95% confidence
interval [CI], 1.01 to 11.8; p = 0.048) and at 24 h after lung allograft reperfusion (OR, 4.8; 95% CI, 1.4 to 16.1; p = 0.01).
Higher preoperative mean pulmonary artery pressure and the use of cardiopulmonary bypass were also associated with an increased
risk of PGD.
Conclusion: Higher postoperative soluble P-selectin levels were associated with an increased risk of PGD at 72 h following lung transplantation. |
| doi_str_mv | 10.1378/chest.08-2697 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2821286</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>67464346</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-63d7489577e9b419211762367f260361752c397abd30820fa0f944bd097984f63</originalsourceid><addsrcrecordid>eNpVkc1v1DAUxC0EokvhyBX5Are0_oodX5CqAgVpJSpaxNFyHHvj4rUXOwH1v8chqwIny3o_zZs3A8BLjM4wFd25GW2ZzlDXEC7FI7DBkuKGtow-BhuEMGkol-QEPCvlDtU_lvwpOMGStC2RfAO-3aQw98HC6-bGBmsmH6GOA5xGC7_48h0mB6-z3-t8D6-ydhN8d1_cHCuYIrxwk81wO8cdvM06lkPQcdLL6Dl44nQo9sXxPQVfP7y_vfzYbD9ffbq82DaGte3UcDoI1slWCCt7Vm1hLDihXDjCEeVYtMRQKXQ_UNQR5DRykrF-QFLIjjlOT8HbVfcw93s7GBunrIM6rJZV0l79P4l-VLv0U5GOYNItAm-OAjn9mGuWau-LsaFeYtNcFBeMM8oWsFlBk1Mp2bqHJRippQr1pwqFOrVUUflX_zr7Sx-zr8DrI6CL0cHVAI0vDxxZjpeUVO585Ua_G3_5bFXZ6xCqLF1X3qU5Rx0w5QorQgX9DSJAoxQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67464346</pqid></control><display><type>article</type><title>Soluble P-Selectin and the Risk of Primary Graft Dysfunction After Lung Transplantation</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>KAWUT, Steven M ; OKUN, Jeffrey ; DEMISSIE, Ejigayehu ; CHRISTIE, Jason D ; SHIMBO, Daichi ; LEDERER, David J ; DE ANDRADE, Joao ; LAMA, Vibha ; SHAH, Ashish ; MILSTONE, Aaron ; WARE, Lorraine B ; WEINACKER, Ann</creator><creatorcontrib>KAWUT, Steven M ; OKUN, Jeffrey ; DEMISSIE, Ejigayehu ; CHRISTIE, Jason D ; SHIMBO, Daichi ; LEDERER, David J ; DE ANDRADE, Joao ; LAMA, Vibha ; SHAH, Ashish ; MILSTONE, Aaron ; WARE, Lorraine B ; WEINACKER, Ann ; Lung Transplant Outcomes Group</creatorcontrib><description>Background: Platelet activation with subsequent neutrophilic adherence to the vasculature initiates ischemia-reperfusion injury. We hypothesized
that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction
(PGD) after lung transplantation.
Methods: In a prospective, multicenter cohort study of 376 patients who had undergone lung transplantation between 2002 and 2007,
we measured soluble P-selectin levels before lung transplantation and at 6 and 24 h after lung reperfusion in 20 patients
with grade III PGD (Pa o 2 /fraction of inspired oxygen, < 200 mm Hg [with alveolar infiltrates seen on chest radiographs]) at 72 h after transplantation
and 61 control subjects without PGD.
Results: Higher postoperative soluble P-selectin levels were associated with an increased risk of PGD at 72 h after transplantation
(odds ratio [OR] per 1 natural log increase in soluble P-selectin at 6 h after lung allograft reperfusion, 3.5; 95% confidence
interval [CI], 1.01 to 11.8; p = 0.048) and at 24 h after lung allograft reperfusion (OR, 4.8; 95% CI, 1.4 to 16.1; p = 0.01).
Higher preoperative mean pulmonary artery pressure and the use of cardiopulmonary bypass were also associated with an increased
risk of PGD.
Conclusion: Higher postoperative soluble P-selectin levels were associated with an increased risk of PGD at 72 h following lung transplantation.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.08-2697</identifier><identifier>PMID: 19255296</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: American College of Chest Physicians</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cardiology. Vascular system ; Case-Control Studies ; Cohort Studies ; Female ; Humans ; Logistic Models ; Lung Diseases - blood ; Lung Diseases - pathology ; Lung Diseases - surgery ; Lung Transplantation - adverse effects ; Male ; Medical sciences ; Middle Aged ; Original Research ; P-Selectin - blood ; Platelet Activation ; Pneumology ; Primary Graft Dysfunction - blood ; Primary Graft Dysfunction - etiology ; Risk Factors</subject><ispartof>Chest, 2009-07, Vol.136 (1), p.237-244</ispartof><rights>2009 INIST-CNRS</rights><rights>2009 American College of Chest Physicians</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-63d7489577e9b419211762367f260361752c397abd30820fa0f944bd097984f63</citedby><cites>FETCH-LOGICAL-c455t-63d7489577e9b419211762367f260361752c397abd30820fa0f944bd097984f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21752932$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19255296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAWUT, Steven M</creatorcontrib><creatorcontrib>OKUN, Jeffrey</creatorcontrib><creatorcontrib>DEMISSIE, Ejigayehu</creatorcontrib><creatorcontrib>CHRISTIE, Jason D</creatorcontrib><creatorcontrib>SHIMBO, Daichi</creatorcontrib><creatorcontrib>LEDERER, David J</creatorcontrib><creatorcontrib>DE ANDRADE, Joao</creatorcontrib><creatorcontrib>LAMA, Vibha</creatorcontrib><creatorcontrib>SHAH, Ashish</creatorcontrib><creatorcontrib>MILSTONE, Aaron</creatorcontrib><creatorcontrib>WARE, Lorraine B</creatorcontrib><creatorcontrib>WEINACKER, Ann</creatorcontrib><creatorcontrib>Lung Transplant Outcomes Group</creatorcontrib><title>Soluble P-Selectin and the Risk of Primary Graft Dysfunction After Lung Transplantation</title><title>Chest</title><addtitle>Chest</addtitle><description>Background: Platelet activation with subsequent neutrophilic adherence to the vasculature initiates ischemia-reperfusion injury. We hypothesized
that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction
(PGD) after lung transplantation.
Methods: In a prospective, multicenter cohort study of 376 patients who had undergone lung transplantation between 2002 and 2007,
we measured soluble P-selectin levels before lung transplantation and at 6 and 24 h after lung reperfusion in 20 patients
with grade III PGD (Pa o 2 /fraction of inspired oxygen, < 200 mm Hg [with alveolar infiltrates seen on chest radiographs]) at 72 h after transplantation
and 61 control subjects without PGD.
Results: Higher postoperative soluble P-selectin levels were associated with an increased risk of PGD at 72 h after transplantation
(odds ratio [OR] per 1 natural log increase in soluble P-selectin at 6 h after lung allograft reperfusion, 3.5; 95% confidence
interval [CI], 1.01 to 11.8; p = 0.048) and at 24 h after lung allograft reperfusion (OR, 4.8; 95% CI, 1.4 to 16.1; p = 0.01).
Higher preoperative mean pulmonary artery pressure and the use of cardiopulmonary bypass were also associated with an increased
risk of PGD.
Conclusion: Higher postoperative soluble P-selectin levels were associated with an increased risk of PGD at 72 h following lung transplantation.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Case-Control Studies</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Lung Diseases - blood</subject><subject>Lung Diseases - pathology</subject><subject>Lung Diseases - surgery</subject><subject>Lung Transplantation - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Original Research</subject><subject>P-Selectin - blood</subject><subject>Platelet Activation</subject><subject>Pneumology</subject><subject>Primary Graft Dysfunction - blood</subject><subject>Primary Graft Dysfunction - etiology</subject><subject>Risk Factors</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1v1DAUxC0EokvhyBX5Are0_oodX5CqAgVpJSpaxNFyHHvj4rUXOwH1v8chqwIny3o_zZs3A8BLjM4wFd25GW2ZzlDXEC7FI7DBkuKGtow-BhuEMGkol-QEPCvlDtU_lvwpOMGStC2RfAO-3aQw98HC6-bGBmsmH6GOA5xGC7_48h0mB6-z3-t8D6-ydhN8d1_cHCuYIrxwk81wO8cdvM06lkPQcdLL6Dl44nQo9sXxPQVfP7y_vfzYbD9ffbq82DaGte3UcDoI1slWCCt7Vm1hLDihXDjCEeVYtMRQKXQ_UNQR5DRykrF-QFLIjjlOT8HbVfcw93s7GBunrIM6rJZV0l79P4l-VLv0U5GOYNItAm-OAjn9mGuWau-LsaFeYtNcFBeMM8oWsFlBk1Mp2bqHJRippQr1pwqFOrVUUflX_zr7Sx-zr8DrI6CL0cHVAI0vDxxZjpeUVO585Ua_G3_5bFXZ6xCqLF1X3qU5Rx0w5QorQgX9DSJAoxQ</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>KAWUT, Steven M</creator><creator>OKUN, Jeffrey</creator><creator>DEMISSIE, Ejigayehu</creator><creator>CHRISTIE, Jason D</creator><creator>SHIMBO, Daichi</creator><creator>LEDERER, David J</creator><creator>DE ANDRADE, Joao</creator><creator>LAMA, Vibha</creator><creator>SHAH, Ashish</creator><creator>MILSTONE, Aaron</creator><creator>WARE, Lorraine B</creator><creator>WEINACKER, Ann</creator><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090701</creationdate><title>Soluble P-Selectin and the Risk of Primary Graft Dysfunction After Lung Transplantation</title><author>KAWUT, Steven M ; OKUN, Jeffrey ; DEMISSIE, Ejigayehu ; CHRISTIE, Jason D ; SHIMBO, Daichi ; LEDERER, David J ; DE ANDRADE, Joao ; LAMA, Vibha ; SHAH, Ashish ; MILSTONE, Aaron ; WARE, Lorraine B ; WEINACKER, Ann</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-63d7489577e9b419211762367f260361752c397abd30820fa0f944bd097984f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Case-Control Studies</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Lung Diseases - blood</topic><topic>Lung Diseases - pathology</topic><topic>Lung Diseases - surgery</topic><topic>Lung Transplantation - adverse effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Original Research</topic><topic>P-Selectin - blood</topic><topic>Platelet Activation</topic><topic>Pneumology</topic><topic>Primary Graft Dysfunction - blood</topic><topic>Primary Graft Dysfunction - etiology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAWUT, Steven M</creatorcontrib><creatorcontrib>OKUN, Jeffrey</creatorcontrib><creatorcontrib>DEMISSIE, Ejigayehu</creatorcontrib><creatorcontrib>CHRISTIE, Jason D</creatorcontrib><creatorcontrib>SHIMBO, Daichi</creatorcontrib><creatorcontrib>LEDERER, David J</creatorcontrib><creatorcontrib>DE ANDRADE, Joao</creatorcontrib><creatorcontrib>LAMA, Vibha</creatorcontrib><creatorcontrib>SHAH, Ashish</creatorcontrib><creatorcontrib>MILSTONE, Aaron</creatorcontrib><creatorcontrib>WARE, Lorraine B</creatorcontrib><creatorcontrib>WEINACKER, Ann</creatorcontrib><creatorcontrib>Lung Transplant Outcomes Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAWUT, Steven M</au><au>OKUN, Jeffrey</au><au>DEMISSIE, Ejigayehu</au><au>CHRISTIE, Jason D</au><au>SHIMBO, Daichi</au><au>LEDERER, David J</au><au>DE ANDRADE, Joao</au><au>LAMA, Vibha</au><au>SHAH, Ashish</au><au>MILSTONE, Aaron</au><au>WARE, Lorraine B</au><au>WEINACKER, Ann</au><aucorp>Lung Transplant Outcomes Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble P-Selectin and the Risk of Primary Graft Dysfunction After Lung Transplantation</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>136</volume><issue>1</issue><spage>237</spage><epage>244</epage><pages>237-244</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Background: Platelet activation with subsequent neutrophilic adherence to the vasculature initiates ischemia-reperfusion injury. We hypothesized
that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction
(PGD) after lung transplantation.
Methods: In a prospective, multicenter cohort study of 376 patients who had undergone lung transplantation between 2002 and 2007,
we measured soluble P-selectin levels before lung transplantation and at 6 and 24 h after lung reperfusion in 20 patients
with grade III PGD (Pa o 2 /fraction of inspired oxygen, < 200 mm Hg [with alveolar infiltrates seen on chest radiographs]) at 72 h after transplantation
and 61 control subjects without PGD.
Results: Higher postoperative soluble P-selectin levels were associated with an increased risk of PGD at 72 h after transplantation
(odds ratio [OR] per 1 natural log increase in soluble P-selectin at 6 h after lung allograft reperfusion, 3.5; 95% confidence
interval [CI], 1.01 to 11.8; p = 0.048) and at 24 h after lung allograft reperfusion (OR, 4.8; 95% CI, 1.4 to 16.1; p = 0.01).
Higher preoperative mean pulmonary artery pressure and the use of cardiopulmonary bypass were also associated with an increased
risk of PGD.
Conclusion: Higher postoperative soluble P-selectin levels were associated with an increased risk of PGD at 72 h following lung transplantation.</abstract><cop>Northbrook, IL</cop><pub>American College of Chest Physicians</pub><pmid>19255296</pmid><doi>10.1378/chest.08-2697</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Chest, 2009-07, Vol.136 (1), p.237-244 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged Biological and medical sciences Cardiology. Vascular system Case-Control Studies Cohort Studies Female Humans Logistic Models Lung Diseases - blood Lung Diseases - pathology Lung Diseases - surgery Lung Transplantation - adverse effects Male Medical sciences Middle Aged Original Research P-Selectin - blood Platelet Activation Pneumology Primary Graft Dysfunction - blood Primary Graft Dysfunction - etiology Risk Factors |
| title | Soluble P-Selectin and the Risk of Primary Graft Dysfunction After Lung Transplantation |
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