Aggregation of actin and cofilin in identical twins with juvenile-onset dystonia

The neuropathology of the primary dystonias is not well understood. We examined brains from identical twins with DYT1‐negative, dopa‐unresponsive dystonia. The twins exhibited mild developmental delays until age 12 years when they began developing rapidly progressive generalized dystonia. Genetic, m...

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Veröffentlicht in:	Annals of neurology 2002-10, Vol.52 (4), p.465-476
Hauptverfasser:	Gearing, Marla, Juncos, Jorge L., Procaccio, Vincent, Gutekunst, Claire-Anne, Marino-Rodriguez, Elaine M., Gyure, Kymberly A., Ono, Shoichiro, Santoianni, Robert, Krawiecki, Nicolas S., Wallace, Douglas C., Wainer, Bruce H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Depolymerizing Factors Actins - analysis Adult Biological and medical sciences Cholinergic Antagonists - therapeutic use Diseases of striated muscles. Neuromuscular diseases Dystonic Disorders - drug therapy Dystonic Disorders - metabolism Dystonic Disorders - pathology Family Health Humans Inclusion Bodies - chemistry Inclusion Bodies - pathology Inclusion Bodies - ultrastructure Medical sciences Microfilament Proteins - analysis Microscopy, Electron Nerve Degeneration - drug therapy Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurology Neurons - chemistry Neurons - pathology Neurons - ultrastructure Neuropil - chemistry Neuropil - pathology Neuropil - ultrastructure Parasympatholytics - therapeutic use Phenotype Twins, Monozygotic
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