A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog

Trisomy 21 results in phenotypes collectively referred to as Down syndrome (DS) including characteristic facial dysmorphology. Ts65Dn mice are trisomic for orthologs of about half of the genes found on human chromosome 21 and exhibit DS-like craniofacial abnormalities, including a small dysmorphic m...

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Veröffentlicht in:	Mechanisms of development 2009-03, Vol.126 (3), p.212-219
Hauptverfasser:	Roper, Randall J., VanHorn, Justin F., Cain, Colyn C., Reeves, Roger H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Branchial Region - embryology Branchial Region - metabolism Branchial Region - pathology Cell Proliferation Down syndrome Down Syndrome - embryology Down Syndrome - metabolism Down Syndrome - pathology Embryo, Mammalian - metabolism Embryo, Mammalian - pathology Female Hedgehog Proteins - metabolism Male Mandibular development Mice Mitosis Neural crest Neural Crest - embryology Neural Crest - metabolism Neural Crest - pathology Neural Tube - embryology Neural Tube - metabolism Neural Tube - pathology Organ Specificity Phenotype Sonic hedgehog Time Factors Trisomy - pathology Trisomy 21
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