Memory Encoding and Dopamine in the Aging Brain: A Psychopharmacological Neuroimaging Study
Normal aging brings with it changes in dopaminergic and memory functions. However, little is known about how these 2 changes are related. In this study, we identify a link between dopamine, episodic memory networks, and aging, using pharmacological functional magnetic resonance imaging. Young and ol...
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| Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2010-03, Vol.20 (3), p.743-757 |
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| container_title | Cerebral cortex (New York, N.Y. 1991) |
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| creator | Morcom, Alexa M. Bullmore, Edward T. Huppert, Felicia A. Lennox, Belinda Praseedom, Asha Linnington, Helen Fletcher, Paul C. |
| description | Normal aging brings with it changes in dopaminergic and memory functions. However, little is known about how these 2 changes are related. In this study, we identify a link between dopamine, episodic memory networks, and aging, using pharmacological functional magnetic resonance imaging. Young and older adults received a D2-like agonist (Bromocriptine, 1.25 mg), a D2-like antagonist (Sulpiride, 400 mg), and Placebo, in a double-blind crossover procedure. We observed group differences, during memory encoding, in medial temporal, frontal, and striatal regions and moreover, these regions were differentially sensitive across groups to dopaminergic perturbation. These findings suggest that brain systems underlying memory show age-related changes and that dopaminergic function may be key in understanding these changes. That these changes have behavioral consequences was suggested by the observation that drug modulations were most pronounced in older subjects with poorer recognition memory. Our findings provide direct evidence linking ageing, memory, and dopaminergic change. |
| doi_str_mv | 10.1093/cercor/bhp139 |
| format | Article |
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However, little is known about how these 2 changes are related. In this study, we identify a link between dopamine, episodic memory networks, and aging, using pharmacological functional magnetic resonance imaging. Young and older adults received a D2-like agonist (Bromocriptine, 1.25 mg), a D2-like antagonist (Sulpiride, 400 mg), and Placebo, in a double-blind crossover procedure. We observed group differences, during memory encoding, in medial temporal, frontal, and striatal regions and moreover, these regions were differentially sensitive across groups to dopaminergic perturbation. These findings suggest that brain systems underlying memory show age-related changes and that dopaminergic function may be key in understanding these changes. That these changes have behavioral consequences was suggested by the observation that drug modulations were most pronounced in older subjects with poorer recognition memory. Our findings provide direct evidence linking ageing, memory, and dopaminergic change.</description><identifier>ISSN: 1047-3211</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhp139</identifier><identifier>PMID: 19625385</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adolescent ; Adult ; Aged ; aging ; Aging - drug effects ; Aging - physiology ; Analysis of Variance ; Brain - blood supply ; Brain - drug effects ; Brain - physiology ; Brain Mapping ; Cross-Over Studies ; Domperidone - pharmacology ; dopamine ; Dopamine - metabolism ; Dopamine Antagonists - pharmacology ; Double-Blind Method ; encoding ; Female ; fMRI ; Humans ; Image Processing, Computer-Assisted - methods ; Magnetic Resonance Imaging - methods ; Male ; memory ; Memory - drug effects ; Memory - physiology ; Middle Aged ; Models, Statistical ; Neuropsychological Tests ; Oxygen - blood ; Photic Stimulation - methods ; Prolactin - blood ; Young Adult</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2010-03, Vol.20 (3), p.743-757</ispartof><rights>2009 The Authors 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-6d3812321cdbc097800d4eb52bd31e56f3592528154f7201a3417292c5a701c43</citedby><cites>FETCH-LOGICAL-c555t-6d3812321cdbc097800d4eb52bd31e56f3592528154f7201a3417292c5a701c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19625385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morcom, Alexa M.</creatorcontrib><creatorcontrib>Bullmore, Edward T.</creatorcontrib><creatorcontrib>Huppert, Felicia A.</creatorcontrib><creatorcontrib>Lennox, Belinda</creatorcontrib><creatorcontrib>Praseedom, Asha</creatorcontrib><creatorcontrib>Linnington, Helen</creatorcontrib><creatorcontrib>Fletcher, Paul C.</creatorcontrib><title>Memory Encoding and Dopamine in the Aging Brain: A Psychopharmacological Neuroimaging Study</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Normal aging brings with it changes in dopaminergic and memory functions. However, little is known about how these 2 changes are related. In this study, we identify a link between dopamine, episodic memory networks, and aging, using pharmacological functional magnetic resonance imaging. Young and older adults received a D2-like agonist (Bromocriptine, 1.25 mg), a D2-like antagonist (Sulpiride, 400 mg), and Placebo, in a double-blind crossover procedure. We observed group differences, during memory encoding, in medial temporal, frontal, and striatal regions and moreover, these regions were differentially sensitive across groups to dopaminergic perturbation. These findings suggest that brain systems underlying memory show age-related changes and that dopaminergic function may be key in understanding these changes. That these changes have behavioral consequences was suggested by the observation that drug modulations were most pronounced in older subjects with poorer recognition memory. Our findings provide direct evidence linking ageing, memory, and dopaminergic change.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>aging</subject><subject>Aging - drug effects</subject><subject>Aging - physiology</subject><subject>Analysis of Variance</subject><subject>Brain - blood supply</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>Brain Mapping</subject><subject>Cross-Over Studies</subject><subject>Domperidone - pharmacology</subject><subject>dopamine</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Double-Blind Method</subject><subject>encoding</subject><subject>Female</subject><subject>fMRI</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>memory</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Middle Aged</subject><subject>Models, Statistical</subject><subject>Neuropsychological Tests</subject><subject>Oxygen - blood</subject><subject>Photic Stimulation - methods</subject><subject>Prolactin - blood</subject><subject>Young Adult</subject><issn>1047-3211</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1v1DAQxS0EoqVw5Ip8g0uoP2I75oC0LYWilrairUDlYDmOd-M2sYOdIPa_x21WBU49zUjz05s38wB4idFbjCTdNTaaEHfrdsBUPgLbuOSoIFjKx7lHpSgowXgLPEvpGiEsCCNPwRaWnDBasW3w44vtQ1zDA29C4_wKat_AD2HQvfMWOg_H1sLF6nayF7Xz7-ACnqW1acPQ6thrE7qwckZ38MROMbhe37Hn49Ssn4MnS90l-2JTd8Dlx4OL_cPi-PTT5_3FcWEYY2PBG1phkm2apjZIigqhprQ1I3VDsWV8SZnMtivMyqUgCGta5jskMUwLhE1Jd8D7WXeY6t42xvox6k4NMbuJaxW0U_9PvGvVKvxSpCJIoCoLvN4IxPBzsmlUvUvGdp32NkxJiZITSvNjHyYplZRzxDJZzKSJIaVol_d-MFK3yak5OTUnl_lX_x7xl95ElYE3MxCm4UGtzW6XRvv7HtbxRnFBBVOH36_Ut6ujil18PVGc_gHrD7ND</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Morcom, Alexa M.</creator><creator>Bullmore, Edward T.</creator><creator>Huppert, Felicia A.</creator><creator>Lennox, Belinda</creator><creator>Praseedom, Asha</creator><creator>Linnington, Helen</creator><creator>Fletcher, Paul C.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20100301</creationdate><title>Memory Encoding and Dopamine in the Aging Brain: A Psychopharmacological Neuroimaging Study</title><author>Morcom, Alexa M. ; Bullmore, Edward T. ; Huppert, Felicia A. ; Lennox, Belinda ; Praseedom, Asha ; Linnington, Helen ; Fletcher, Paul C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555t-6d3812321cdbc097800d4eb52bd31e56f3592528154f7201a3417292c5a701c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>aging</topic><topic>Aging - drug effects</topic><topic>Aging - physiology</topic><topic>Analysis of Variance</topic><topic>Brain - blood supply</topic><topic>Brain - drug effects</topic><topic>Brain - physiology</topic><topic>Brain Mapping</topic><topic>Cross-Over Studies</topic><topic>Domperidone - pharmacology</topic><topic>dopamine</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Double-Blind Method</topic><topic>encoding</topic><topic>Female</topic><topic>fMRI</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>memory</topic><topic>Memory - drug effects</topic><topic>Memory - physiology</topic><topic>Middle Aged</topic><topic>Models, Statistical</topic><topic>Neuropsychological Tests</topic><topic>Oxygen - blood</topic><topic>Photic Stimulation - methods</topic><topic>Prolactin - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morcom, Alexa M.</creatorcontrib><creatorcontrib>Bullmore, Edward T.</creatorcontrib><creatorcontrib>Huppert, Felicia A.</creatorcontrib><creatorcontrib>Lennox, Belinda</creatorcontrib><creatorcontrib>Praseedom, Asha</creatorcontrib><creatorcontrib>Linnington, Helen</creatorcontrib><creatorcontrib>Fletcher, Paul C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morcom, Alexa M.</au><au>Bullmore, Edward T.</au><au>Huppert, Felicia A.</au><au>Lennox, Belinda</au><au>Praseedom, Asha</au><au>Linnington, Helen</au><au>Fletcher, Paul C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Memory Encoding and Dopamine in the Aging Brain: A Psychopharmacological Neuroimaging Study</atitle><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle><addtitle>Cereb Cortex</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>20</volume><issue>3</issue><spage>743</spage><epage>757</epage><pages>743-757</pages><issn>1047-3211</issn><eissn>1460-2199</eissn><abstract>Normal aging brings with it changes in dopaminergic and memory functions. However, little is known about how these 2 changes are related. In this study, we identify a link between dopamine, episodic memory networks, and aging, using pharmacological functional magnetic resonance imaging. Young and older adults received a D2-like agonist (Bromocriptine, 1.25 mg), a D2-like antagonist (Sulpiride, 400 mg), and Placebo, in a double-blind crossover procedure. We observed group differences, during memory encoding, in medial temporal, frontal, and striatal regions and moreover, these regions were differentially sensitive across groups to dopaminergic perturbation. These findings suggest that brain systems underlying memory show age-related changes and that dopaminergic function may be key in understanding these changes. That these changes have behavioral consequences was suggested by the observation that drug modulations were most pronounced in older subjects with poorer recognition memory. 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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged aging Aging - drug effects Aging - physiology Analysis of Variance Brain - blood supply Brain - drug effects Brain - physiology Brain Mapping Cross-Over Studies Domperidone - pharmacology dopamine Dopamine - metabolism Dopamine Antagonists - pharmacology Double-Blind Method encoding Female fMRI Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male memory Memory - drug effects Memory - physiology Middle Aged Models, Statistical Neuropsychological Tests Oxygen - blood Photic Stimulation - methods Prolactin - blood Young Adult |
| title | Memory Encoding and Dopamine in the Aging Brain: A Psychopharmacological Neuroimaging Study |
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