Copy number variant detection in inbred strains from short read sequence data

We have developed an algorithm to detect copy number variants (CNVs) in homozygous organisms, such as inbred laboratory strains of mice, from short read sequence data. Our novel approach exploits the fact that inbred mice are homozygous at virtually every position in the genome to detect CNVs using...

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Veröffentlicht in:	Bioinformatics 2010-02, Vol.26 (4), p.565-567
Hauptverfasser:	Simpson, Jared T., McIntyre, Rebecca E., Adams, David J., Durbin, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Applications Note Base Sequence Biological and medical sciences DNA Copy Number Variations Fundamental and applied biological sciences. Psychology Gene Dosage General aspects Genetic Variation Mathematics in biology. Statistical analysis. Models. Metrology. Data processing in biology (general aspects) Mice Mice, Inbred Strains - genetics Sequence Analysis, DNA
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