Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA
Objective. RA is associated with localized bone loss in the hands, as well as generalized osteoporosis. We evaluated the relationship between hand digital X-ray radiogrammetry BMD (DXR-BMD) and total hip and lumbar spine BMD. Methods. We conducted a cross-sectional study of 138 post-menopausal women...
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| Veröffentlicht in: | Rheumatology (Oxford, England) England), 2010-03, Vol.49 (3), p.513-519 |
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| creator | Desai, Sonali P. Gravallese, Ellen M. Shadick, Nancy A. Glass, Roberta Cui, Jing Frits, Michelle Chibnik, Lori B. Maher, Nancy Weinblatt, Michael E. Solomon, Daniel H. |
| description | Objective. RA is associated with localized bone loss in the hands, as well as generalized osteoporosis. We evaluated the relationship between hand digital X-ray radiogrammetry BMD (DXR-BMD) and total hip and lumbar spine BMD. Methods. We conducted a cross-sectional study of 138 post-menopausal women with RA. The DXR-BMD was calculated based on digitized hand radiographs. Measurements of the total hip and lumbar spine BMD were performed by a DXA-BMD (BMDa) scan. Patient and physician questionnaires and laboratory samples supplied information on relevant covariates. Separate multivariate linear regression models were constructed to determine the cross-sectional relationship between hand DXR-BMD (independent variable) and total hip or lumbar spine BMD (dependent variables). Results. The cohort comprised women with a median age of 61 years and RA disease duration of 13 years. Seventy-six per cent were either RF and/or anti-cyclic citrullinated peptide (anti-CCP) positive and most had moderate disease activity [median disease activity score-28 joint count (DAS28) 3.7]. Hand DXR-BMD was significantly associated with total hip BMD (β = 0.61; P < 0.0001) and lumbar spine BMD (β = 0.62; P < 0.0008) in adjusted models. Conclusions. This study suggests that hand DXR-BMD is associated with both the total hip and lumbar spine BMD among post-menopausal women with RA. The relationship between bone loss in the hands and generalized osteoporosis should be further explored in longitudinal studies of patients with RA. |
| doi_str_mv | 10.1093/rheumatology/kep385 |
| format | Article |
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RA is associated with localized bone loss in the hands, as well as generalized osteoporosis. We evaluated the relationship between hand digital X-ray radiogrammetry BMD (DXR-BMD) and total hip and lumbar spine BMD. Methods. We conducted a cross-sectional study of 138 post-menopausal women with RA. The DXR-BMD was calculated based on digitized hand radiographs. Measurements of the total hip and lumbar spine BMD were performed by a DXA-BMD (BMDa) scan. Patient and physician questionnaires and laboratory samples supplied information on relevant covariates. Separate multivariate linear regression models were constructed to determine the cross-sectional relationship between hand DXR-BMD (independent variable) and total hip or lumbar spine BMD (dependent variables). Results. The cohort comprised women with a median age of 61 years and RA disease duration of 13 years. Seventy-six per cent were either RF and/or anti-cyclic citrullinated peptide (anti-CCP) positive and most had moderate disease activity [median disease activity score-28 joint count (DAS28) 3.7]. Hand DXR-BMD was significantly associated with total hip BMD (β = 0.61; P < 0.0001) and lumbar spine BMD (β = 0.62; P < 0.0008) in adjusted models. Conclusions. This study suggests that hand DXR-BMD is associated with both the total hip and lumbar spine BMD among post-menopausal women with RA. The relationship between bone loss in the hands and generalized osteoporosis should be further explored in longitudinal studies of patients with RA.</description><identifier>ISSN: 1462-0324</identifier><identifier>EISSN: 1462-0332</identifier><identifier>DOI: 10.1093/rheumatology/kep385</identifier><identifier>PMID: 20026562</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Absorptiometry, Photon ; Age Factors ; Aged ; Arthritis, Rheumatoid - physiopathology ; Biological and medical sciences ; Bone Density - physiology ; Bone mineral density ; Clinical Science ; Cross-Sectional Studies ; Digital X-ray radiogrammetry ; Diseases of the osteoarticular system ; Epidemiologic Methods ; Female ; Hand bone loss ; Hip Joint - physiopathology ; Humans ; Inflammatory joint diseases ; Investigative techniques, diagnostic techniques (general aspects) ; Lumbar Vertebrae - physiopathology ; Medical sciences ; Metacarpal Bones - physiopathology ; Middle Aged ; Osteoarticular system. Muscles ; Osteoporosis ; Osteoporosis. Osteomalacia. Paget disease ; Postmenopause - physiology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rheumatoid arthritis ; Time Factors</subject><ispartof>Rheumatology (Oxford, England), 2010-03, Vol.49 (3), p.513-519</ispartof><rights>The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org 2009</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-df590d9af056723e98b8117e8647c73ec497eea7205eeb39dfcf680e9047566b3</citedby><cites>FETCH-LOGICAL-c511t-df590d9af056723e98b8117e8647c73ec497eea7205eeb39dfcf680e9047566b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,1585,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22533102$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20026562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Desai, Sonali P.</creatorcontrib><creatorcontrib>Gravallese, Ellen M.</creatorcontrib><creatorcontrib>Shadick, Nancy A.</creatorcontrib><creatorcontrib>Glass, Roberta</creatorcontrib><creatorcontrib>Cui, Jing</creatorcontrib><creatorcontrib>Frits, Michelle</creatorcontrib><creatorcontrib>Chibnik, Lori B.</creatorcontrib><creatorcontrib>Maher, Nancy</creatorcontrib><creatorcontrib>Weinblatt, Michael E.</creatorcontrib><creatorcontrib>Solomon, Daniel H.</creatorcontrib><title>Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA</title><title>Rheumatology (Oxford, England)</title><addtitle>Rheumatology (Oxford)</addtitle><description>Objective. RA is associated with localized bone loss in the hands, as well as generalized osteoporosis. We evaluated the relationship between hand digital X-ray radiogrammetry BMD (DXR-BMD) and total hip and lumbar spine BMD. Methods. We conducted a cross-sectional study of 138 post-menopausal women with RA. The DXR-BMD was calculated based on digitized hand radiographs. Measurements of the total hip and lumbar spine BMD were performed by a DXA-BMD (BMDa) scan. Patient and physician questionnaires and laboratory samples supplied information on relevant covariates. Separate multivariate linear regression models were constructed to determine the cross-sectional relationship between hand DXR-BMD (independent variable) and total hip or lumbar spine BMD (dependent variables). Results. The cohort comprised women with a median age of 61 years and RA disease duration of 13 years. Seventy-six per cent were either RF and/or anti-cyclic citrullinated peptide (anti-CCP) positive and most had moderate disease activity [median disease activity score-28 joint count (DAS28) 3.7]. Hand DXR-BMD was significantly associated with total hip BMD (β = 0.61; P < 0.0001) and lumbar spine BMD (β = 0.62; P < 0.0008) in adjusted models. Conclusions. This study suggests that hand DXR-BMD is associated with both the total hip and lumbar spine BMD among post-menopausal women with RA. The relationship between bone loss in the hands and generalized osteoporosis should be further explored in longitudinal studies of patients with RA.</description><subject>Absorptiometry, Photon</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Arthritis, Rheumatoid - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bone Density - physiology</subject><subject>Bone mineral density</subject><subject>Clinical Science</subject><subject>Cross-Sectional Studies</subject><subject>Digital X-ray radiogrammetry</subject><subject>Diseases of the osteoarticular system</subject><subject>Epidemiologic Methods</subject><subject>Female</subject><subject>Hand bone loss</subject><subject>Hip Joint - physiopathology</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lumbar Vertebrae - physiopathology</subject><subject>Medical sciences</subject><subject>Metacarpal Bones - physiopathology</subject><subject>Middle Aged</subject><subject>Osteoarticular system. Muscles</subject><subject>Osteoporosis</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Postmenopause - physiology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rheumatoid arthritis</subject><subject>Time Factors</subject><issn>1462-0324</issn><issn>1462-0332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS1ERUvhEyChXBCntP4Tx8kFqSrQpS1CQiCterEcZ9I1TezUdih75ZPjVbbbckDiYns0v_dm5IfQK4KPCK7ZsV_BNKjoene9Pr6BkVX8CTogRUlzzBh9unvTYh89D-EHxpgTVj1D-xRjWvKSHqDfC2XbrHEWssFY8KrPWrDBxHVmQqZCcNqoCG12Z-IqcemILiZqZcZsI-2noVE-C2NS_8PHZqMLMR_AulFNIbXuXCpmy68nL9Bep_oAL7f3Ifr-8cO300V--eXs0-nJZa45ITFvO17jtlYd5qWgDOqqqQgRUJWF0IKBLmoBoATFHKBhddvprqww1LgQvCwbdojezb7j1AzQarAxrSlHbwbl19IpI__uWLOS1-6npBVN38WSwdutgXe3E4QoBxM09L2y4KYgBSuoqBkXiWQzqb0LwUO3m0Kw3IQnH4cn5_CS6vXjBXea-7QS8GYLqKBV33lltQkPHOWMEbzhjmbOTeN_Ts5ngQkRfu0kyt_IUjDB5WJ5Ja_Ol58vlmcX8j37Awl4ytA</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Desai, Sonali P.</creator><creator>Gravallese, Ellen M.</creator><creator>Shadick, Nancy A.</creator><creator>Glass, Roberta</creator><creator>Cui, Jing</creator><creator>Frits, Michelle</creator><creator>Chibnik, Lori B.</creator><creator>Maher, Nancy</creator><creator>Weinblatt, Michael E.</creator><creator>Solomon, Daniel H.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100301</creationdate><title>Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA</title><author>Desai, Sonali P. ; Gravallese, Ellen M. ; Shadick, Nancy A. ; Glass, Roberta ; Cui, Jing ; Frits, Michelle ; Chibnik, Lori B. ; Maher, Nancy ; Weinblatt, Michael E. ; Solomon, Daniel H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-df590d9af056723e98b8117e8647c73ec497eea7205eeb39dfcf680e9047566b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Absorptiometry, Photon</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bone Density - physiology</topic><topic>Bone mineral density</topic><topic>Clinical Science</topic><topic>Cross-Sectional Studies</topic><topic>Digital X-ray radiogrammetry</topic><topic>Diseases of the osteoarticular system</topic><topic>Epidemiologic Methods</topic><topic>Female</topic><topic>Hand bone loss</topic><topic>Hip Joint - physiopathology</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lumbar Vertebrae - physiopathology</topic><topic>Medical sciences</topic><topic>Metacarpal Bones - physiopathology</topic><topic>Middle Aged</topic><topic>Osteoarticular system. Muscles</topic><topic>Osteoporosis</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Postmenopause - physiology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Rheumatoid arthritis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Desai, Sonali P.</creatorcontrib><creatorcontrib>Gravallese, Ellen M.</creatorcontrib><creatorcontrib>Shadick, Nancy A.</creatorcontrib><creatorcontrib>Glass, Roberta</creatorcontrib><creatorcontrib>Cui, Jing</creatorcontrib><creatorcontrib>Frits, Michelle</creatorcontrib><creatorcontrib>Chibnik, Lori B.</creatorcontrib><creatorcontrib>Maher, Nancy</creatorcontrib><creatorcontrib>Weinblatt, Michael E.</creatorcontrib><creatorcontrib>Solomon, Daniel H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Rheumatology (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Desai, Sonali P.</au><au>Gravallese, Ellen M.</au><au>Shadick, Nancy A.</au><au>Glass, Roberta</au><au>Cui, Jing</au><au>Frits, Michelle</au><au>Chibnik, Lori B.</au><au>Maher, Nancy</au><au>Weinblatt, Michael E.</au><au>Solomon, Daniel H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA</atitle><jtitle>Rheumatology (Oxford, England)</jtitle><addtitle>Rheumatology (Oxford)</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>49</volume><issue>3</issue><spage>513</spage><epage>519</epage><pages>513-519</pages><issn>1462-0324</issn><eissn>1462-0332</eissn><abstract>Objective. RA is associated with localized bone loss in the hands, as well as generalized osteoporosis. We evaluated the relationship between hand digital X-ray radiogrammetry BMD (DXR-BMD) and total hip and lumbar spine BMD. Methods. We conducted a cross-sectional study of 138 post-menopausal women with RA. The DXR-BMD was calculated based on digitized hand radiographs. Measurements of the total hip and lumbar spine BMD were performed by a DXA-BMD (BMDa) scan. Patient and physician questionnaires and laboratory samples supplied information on relevant covariates. Separate multivariate linear regression models were constructed to determine the cross-sectional relationship between hand DXR-BMD (independent variable) and total hip or lumbar spine BMD (dependent variables). Results. The cohort comprised women with a median age of 61 years and RA disease duration of 13 years. Seventy-six per cent were either RF and/or anti-cyclic citrullinated peptide (anti-CCP) positive and most had moderate disease activity [median disease activity score-28 joint count (DAS28) 3.7]. Hand DXR-BMD was significantly associated with total hip BMD (β = 0.61; P < 0.0001) and lumbar spine BMD (β = 0.62; P < 0.0008) in adjusted models. Conclusions. This study suggests that hand DXR-BMD is associated with both the total hip and lumbar spine BMD among post-menopausal women with RA. The relationship between bone loss in the hands and generalized osteoporosis should be further explored in longitudinal studies of patients with RA.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>20026562</pmid><doi>10.1093/rheumatology/kep385</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorptiometry, Photon Age Factors Aged Arthritis, Rheumatoid - physiopathology Biological and medical sciences Bone Density - physiology Bone mineral density Clinical Science Cross-Sectional Studies Digital X-ray radiogrammetry Diseases of the osteoarticular system Epidemiologic Methods Female Hand bone loss Hip Joint - physiopathology Humans Inflammatory joint diseases Investigative techniques, diagnostic techniques (general aspects) Lumbar Vertebrae - physiopathology Medical sciences Metacarpal Bones - physiopathology Middle Aged Osteoarticular system. Muscles Osteoporosis Osteoporosis. Osteomalacia. Paget disease Postmenopause - physiology Radiodiagnosis. Nmr imagery. Nmr spectrometry Rheumatoid arthritis Time Factors |
| title | Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA |
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