Deacetylase Inhibitors Dissociate the Histone-Targeting ING2 Subunit from the Sin3 Complex

Histone deacetylase (HDAC) inhibitors are in clinical development for several diseases, including cancers and neurodegenerative disorders. HDACs 1 and 2 are among the targets of these inhibitors and are part of multisubunit protein complexes. HDAC inhibitors (HDACis) block the activity of HDACs by c...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Chemistry & biology 2010-01, Vol.17 (1), p.65-74
Hauptverfasser:	Smith, Karen T., Martin-Brown, Skylar A., Florens, Laurence, Washburn, Michael P., Workman, Jerry L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line CELLBIO CHEMBIO DNA Histone Deacetylase Inhibitors - pharmacology Homeodomain Proteins - metabolism Humans Hydroxamic Acids - pharmacology Promoter Regions, Genetic - drug effects ras Proteins - genetics Receptors, Cytoplasmic and Nuclear - metabolism Sin3 Histone Deacetylase and Corepressor Complex - metabolism Tumor Suppressor Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!