Fractalkine has anti-apoptotic and proliferative effects on human vascular smooth muscle cells via epidermal growth factor receptor signalling

Aims Fractalkine (CX3CL1) is a membrane-bound chemokine that signals through the G protein-coupled receptor CX3CR1 that is implicated in the development of atherosclerosis. We have previously reported that CX3CR1 is expressed by primary human coronary artery smooth muscle cells (CASMC), where it med...

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Veröffentlicht in:	Cardiovascular research 2010-03, Vol.85 (4), p.825-835
Hauptverfasser:	White, Gemma E., Tan, Thomas C.C., John, Alison E., Whatling, Carl, McPheat, William L., Greaves, David R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-apoptosis Apoptosis - physiology Atherosclerosis - metabolism Atherosclerosis - pathology Biological and medical sciences Cardiology. Vascular system Cell Division - physiology Cells, Cultured Chemokine Chemokine CX3CL1 - genetics Chemokine CX3CL1 - metabolism Coronary Vessels - cytology CX3CL1 CX3CR1 EGFR Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Epiregulin Extracellular Signal-Regulated MAP Kinases - metabolism Fractalkine Gene Expression - physiology Humans In Vitro Techniques Medical sciences Mitogens - genetics Mitogens - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Original Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - physiology Proliferation Proto-Oncogene Proteins c-akt - metabolism Receptor, Epidermal Growth Factor - metabolism Signal Transduction - physiology Smooth muscle cell
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