Molecular and genetic substrates linking stress and addiction

Abstract Drug addiction is one of the top three health concerns in the United States in terms of economic and health care costs. Despite this, there are very few effective treatment options available. Therefore, understanding the causes and molecular mechanisms underlying the transition from casual...

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Veröffentlicht in:	Brain research 2010-02, Vol.1314, p.219-234
Hauptverfasser:	Briand, Lisa A, Blendy, Julie A
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Animals BDNF Brain Chemistry - drug effects Brain Chemistry - genetics Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Corticotropin-Releasing Hormone - genetics Corticotropin-Releasing Hormone - metabolism CREB CRF Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Dynorphin Dynorphins - genetics Dynorphins - metabolism Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Humans Neurology Neuronal Plasticity - drug effects Neuronal Plasticity - genetics Stress Stress, Psychological - genetics Stress, Psychological - metabolism Stress, Psychological - physiopathology Substance-Related Disorders - genetics Substance-Related Disorders - metabolism Substance-Related Disorders - physiopathology
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