Reg IV Regulates Normal Intestinal and Colorectal Cancer Cell Susceptibility to Radiation-Induced Apoptosis

Background & Aims Regenerating ( Reg ) gene IV is predominantly expressed in gastrointestinal cells and highly up-regulated in many gastrointestinal malignancies, including colorectal cancer (CRC). Human CRC cells expressing higher levels of Reg IV gene and its protein product (Reg IV) are resis...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2010-02, Vol.138 (2), p.616-626.e2
Hauptverfasser:	Bishnupuri, Kumar S, Luo, Qizhi, Sainathan, Satheesh K, Kikuchi, Kento, Sureban, Sripathi M, Sabarinathan, Mekala, Gross, Jennifer H, Aden, Konrad, May, Randal, Houchen, Courtney W, Anant, Shrikant, Dieckgraefe, Brian K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Adenocarcinoma - radiotherapy Animals Antibodies, Monoclonal - pharmacology Apoptosis - radiation effects bcl-X Protein - metabolism Cell Line, Tumor Cell Proliferation Colon - metabolism Colon - pathology Colorectal Neoplasms - pathology Colorectal Neoplasms - radiotherapy Disease Models, Animal Female Gastroenterology and Hepatology Humans Inhibitor of Apoptosis Proteins Lectins, C-Type - antagonists & inhibitors Lectins, C-Type - metabolism Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Microtubule-Associated Proteins - metabolism Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Pancreatitis-Associated Proteins Proto-Oncogene Proteins c-bcl-2 - metabolism Radiotherapy Repressor Proteins Survivin Transplantation, Heterologous Treatment Outcome
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