FOXOs, cancer and regulation of apoptosis
Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of physiological and pathological processes including cancer. The importance of FOXO factors ascribes them under multiple levels of regulation including phosphorylation, acetyl...
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| Veröffentlicht in: | Oncogene 2008-04, Vol.27 (16), p.2312-2319 |
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| description | Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of physiological and pathological processes including cancer. The importance of FOXO factors ascribes them under multiple levels of regulation including phosphorylation, acetylation/deacetylation, ubiquitination and protein–protein interactions. As FOXO factors play a pivotal role in cell fate decision, mounting evidence suggests that FOXO factors function as tumor suppressors in a variety of cancers. FOXOs are actively involved in promoting apoptosis in a mitochondria-independent and -dependent manner by inducing the expression of death receptor ligands, including Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand, and Bcl-2 family members, such as Bim, bNIP3 and Bcl-X
L
, respectively. An understanding of FOXO proteins and their biology will provide new opportunities for developing more effective therapeutic approaches to treat cancer. |
| doi_str_mv | 10.1038/onc.2008.24 |
| format | Article |
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L
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L
, respectively. An understanding of FOXO proteins and their biology will provide new opportunities for developing more effective therapeutic approaches to treat cancer.</description><subject>Acetylation</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Bcl-2 protein</subject><subject>Bcl-x protein</subject><subject>BIM protein</subject><subject>BNIP3 protein</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Cell Biology</subject><subject>Cell fate</subject><subject>Deacetylation</subject><subject>DNA binding proteins</subject><subject>FasL protein</subject><subject>Forkhead protein</subject><subject>Forkhead Transcription Factors - physiology</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Ligands</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mitochondria</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - physiopathology</subject><subject>Oncology</subject><subject>Phosphorylation</subject><subject>Physiological aspects</subject><subject>Properties</subject><subject>Protein interaction</subject><subject>Proteins</subject><subject>review</subject><subject>Signal transduction</subject><subject>TRAIL protein</subject><subject>Transcription factors</subject><subject>Ubiquitination</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkt9rFDEQx4NY7Fl98l0XBaHYPfNzk7wUSrGtULgXBd9COsmeW_aSM9kV_O-bdQ_PSqUEEsh88p3MzBehVwQvCWbqYwywpBirJeVP0IJw2dRCaP4ULbAWuNaU0UP0POdbjLHUmD5Dh0QxTbRkC3R8sfq2yicV2AA-VTa4Kvn12Nuhi6GKbWW3cTvE3OUX6KC1ffYvd-cR-nrx6cv5VX29uvx8fnZdQ0P5UAtFBFWOeiKdt05qoDeCAwPnmwaEAyK1Ag1YQNklbxSxWDrsHVPgy2eP0Omsux1vNt6BD0OyvdmmbmPTLxNtZ-5HQvfdrONPQxXRHLMi8H4nkOKP0efBbLoMvu9t8HHMRmKuqGb4UZASVjj1OFhaKfCc-t0_4G0cUyjtMrThhKlGc1Got_-lqGSiCPG91Nr23nShjaVYmPKaM6Kx5FrSiVo-QJXl_KaDGHzblft7Dz7MDyDFnJNv_zSWYDPZyRQ7mclO5jf9-u9Z7NmdfwpwMgO5hMLap30pD-u9mfFghzH5_VADTEgh7gDw_tsi</recordid><startdate>20080407</startdate><enddate>20080407</enddate><creator>Fu, Z</creator><creator>Tindall, D J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080407</creationdate><title>FOXOs, cancer and regulation of apoptosis</title><author>Fu, Z ; Tindall, D J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c624t-581528d2e17dead79c2b54c3cde66c5dc1798c9c05cc9c74681a07d0ed38ce923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acetylation</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - physiology</topic><topic>Bcl-2 protein</topic><topic>Bcl-x protein</topic><topic>BIM protein</topic><topic>BNIP3 protein</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Cell Biology</topic><topic>Cell fate</topic><topic>Deacetylation</topic><topic>DNA binding proteins</topic><topic>FasL protein</topic><topic>Forkhead protein</topic><topic>Forkhead Transcription Factors - physiology</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Ligands</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mitochondria</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - physiopathology</topic><topic>Oncology</topic><topic>Phosphorylation</topic><topic>Physiological aspects</topic><topic>Properties</topic><topic>Protein interaction</topic><topic>Proteins</topic><topic>review</topic><topic>Signal transduction</topic><topic>TRAIL protein</topic><topic>Transcription factors</topic><topic>Ubiquitination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Z</creatorcontrib><creatorcontrib>Tindall, D J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Z</au><au>Tindall, D J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FOXOs, cancer and regulation of apoptosis</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2008-04-07</date><risdate>2008</risdate><volume>27</volume><issue>16</issue><spage>2312</spage><epage>2319</epage><pages>2312-2319</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of physiological and pathological processes including cancer. The importance of FOXO factors ascribes them under multiple levels of regulation including phosphorylation, acetylation/deacetylation, ubiquitination and protein–protein interactions. As FOXO factors play a pivotal role in cell fate decision, mounting evidence suggests that FOXO factors function as tumor suppressors in a variety of cancers. FOXOs are actively involved in promoting apoptosis in a mitochondria-independent and -dependent manner by inducing the expression of death receptor ligands, including Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand, and Bcl-2 family members, such as Bim, bNIP3 and Bcl-X
L
, respectively. An understanding of FOXO proteins and their biology will provide new opportunities for developing more effective therapeutic approaches to treat cancer.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18391973</pmid><doi>10.1038/onc.2008.24</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetylation Animals Apoptosis Apoptosis - physiology Bcl-2 protein Bcl-x protein BIM protein BNIP3 protein Cancer Care and treatment Causes of Cell Biology Cell fate Deacetylation DNA binding proteins FasL protein Forkhead protein Forkhead Transcription Factors - physiology Gene expression Genetic aspects Human Genetics Humans Internal Medicine Ligands Medicine Medicine & Public Health Mitochondria Neoplasms - pathology Neoplasms - physiopathology Oncology Phosphorylation Physiological aspects Properties Protein interaction Proteins review Signal transduction TRAIL protein Transcription factors Ubiquitination |
| title | FOXOs, cancer and regulation of apoptosis |
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