Neural Autoantibody Profile of Primary Achalasia
The etiology and pathogenesis of primary achalasia are both unknown. Postulated mechanisms include autoimmune, viral-immune, and central neurodegenerative. The aim of this study is to investigate the serum profile of neural autoantibodies in patients with primary achalasia. Coded sera from 70 patien...
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| Veröffentlicht in: | Digestive diseases and sciences 2010-02, Vol.55 (2), p.307-311 |
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| creator | Kraichely, Robert E. Farrugia, Gianrico Pittock, Sean J. Castell, Donald O. Lennon, Vanda A. |
| description | The etiology and pathogenesis of primary achalasia are both unknown. Postulated mechanisms include autoimmune, viral-immune, and central neurodegenerative. The aim of this study is to investigate the serum profile of neural autoantibodies in patients with primary achalasia. Coded sera from 70 patients with primary achalasia and 161 healthy control subjects, matched in sex, age, and smoking habits, were screened for antibodies targeting neuronal, glial, and muscle autoantigens. No specific myenteric neuronal antibody was identified. However, the overall prevalence of neural autoantibodies in patients with primary achalasia was significantly higher than in healthy control subjects (25.7 vs. 4.4%,
P
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| doi_str_mv | 10.1007/s10620-009-0838-9 |
| format | Article |
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P
< 0.0001). Most noteworthy was the 21.4% frequency of glutamic acid decarboxylase-65 antibody in patients with achalasia (versus 2.5% in control subjects), in the absence of diabetes or companion antibodies predictive of type 1 diabetes. This profile of autoantibodies suggests an autoimmune basis for a subset of primary achalasia.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-009-0838-9</identifier><identifier>PMID: 19499338</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Achalasia ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Autoantibodies ; Autoantibodies - immunology ; Autoantigens ; Autoimmunity ; Autoimmunity - immunology ; Biochemistry ; Biological and medical sciences ; Blotting, Western ; Development and progression ; Enzyme-Linked Immunosorbent Assay ; Esophageal Achalasia - immunology ; Feeding. Feeding behavior ; Female ; Fluorescent Antibody Technique, Indirect ; Fundamental and applied biological sciences. Psychology ; Gastroenterology ; Glutamate ; Hepatology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroglia - immunology ; Neurons ; Oncology ; Original Article ; Radioimmunoprecipitation Assay ; Retrospective Studies ; Transplant Surgery ; Type 1 diabetes ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Young Adult</subject><ispartof>Digestive diseases and sciences, 2010-02, Vol.55 (2), p.307-311</ispartof><rights>Springer Science+Business Media, LLC 2009</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Springer</rights><rights>Springer Science+Business Media, LLC 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c663t-b4d900cbd9a234cf41706ce778afe6dc5f68c616cfd9981b2a338486233869bf3</citedby><cites>FETCH-LOGICAL-c663t-b4d900cbd9a234cf41706ce778afe6dc5f68c616cfd9981b2a338486233869bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10620-009-0838-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10620-009-0838-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22500571$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19499338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kraichely, Robert E.</creatorcontrib><creatorcontrib>Farrugia, Gianrico</creatorcontrib><creatorcontrib>Pittock, Sean J.</creatorcontrib><creatorcontrib>Castell, Donald O.</creatorcontrib><creatorcontrib>Lennon, Vanda A.</creatorcontrib><title>Neural Autoantibody Profile of Primary Achalasia</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><addtitle>Dig Dis Sci</addtitle><description>The etiology and pathogenesis of primary achalasia are both unknown. Postulated mechanisms include autoimmune, viral-immune, and central neurodegenerative. The aim of this study is to investigate the serum profile of neural autoantibodies in patients with primary achalasia. Coded sera from 70 patients with primary achalasia and 161 healthy control subjects, matched in sex, age, and smoking habits, were screened for antibodies targeting neuronal, glial, and muscle autoantigens. No specific myenteric neuronal antibody was identified. However, the overall prevalence of neural autoantibodies in patients with primary achalasia was significantly higher than in healthy control subjects (25.7 vs. 4.4%,
P
< 0.0001). Most noteworthy was the 21.4% frequency of glutamic acid decarboxylase-65 antibody in patients with achalasia (versus 2.5% in control subjects), in the absence of diabetes or companion antibodies predictive of type 1 diabetes. This profile of autoantibodies suggests an autoimmune basis for a subset of primary achalasia.</description><subject>Achalasia</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autoantibodies</subject><subject>Autoantibodies - immunology</subject><subject>Autoantigens</subject><subject>Autoimmunity</subject><subject>Autoimmunity - immunology</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Development and progression</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Esophageal Achalasia - immunology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology</subject><subject>Glutamate</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroglia - immunology</subject><subject>Neurons</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Radioimmunoprecipitation Assay</subject><subject>Retrospective Studies</subject><subject>Transplant Surgery</subject><subject>Type 1 diabetes</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Young Adult</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkl1rFTEQhoNY7PHoD_BGDop4tXXysfm4EQ7FLyjVC70O2WxymrInqcmu0H9v1j20ViwlFxPIM29m3hmEXmA4wQDiXcHACTQAqgFJZaMeoRVuBW1Iy-VjtALM6x1jfoyelnIJFRSYP0HHWDGlKJUrBOduymbYbKcxmTiGLvXXm285-TC4TfL1GvYmX2-29sIMpgTzDB15MxT3_BDX6MfHD99PPzdnXz99Od2eNZZzOjYd6xWA7XplCGXWMyyAWyeENN7x3raeS8sxt75XSuKOmFoOk5zUwFXn6Rq9X3Svpm7veuviWOvUV0s9Opmg777EcKF36ZcmEisiVRV4exDI6efkyqj3oVg3DCa6NBUtWDVJsGrDgyRlhBJe-1qjV_-Ql2nKsfqgCWaUAqez3OsF2pnB6RB9qvXZWVJvBSaKMvjz6cl_qHp6tw82RTdP4G4CXhJsTqVk52-8wKDnddDLOug6ZT2vg549ePm3ibcZh_lX4M0BMMWawWcTbSg3HCEtQCtw5cjClfoUdy7fNn7_778BTQbKCA</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Kraichely, Robert E.</creator><creator>Farrugia, Gianrico</creator><creator>Pittock, Sean J.</creator><creator>Castell, Donald O.</creator><creator>Lennon, Vanda A.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20100201</creationdate><title>Neural Autoantibody Profile of Primary Achalasia</title><author>Kraichely, Robert E. ; Farrugia, Gianrico ; Pittock, Sean J. ; Castell, Donald O. ; Lennon, Vanda A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c663t-b4d900cbd9a234cf41706ce778afe6dc5f68c616cfd9981b2a338486233869bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Achalasia</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autoantibodies</topic><topic>Autoantibodies - immunology</topic><topic>Autoantigens</topic><topic>Autoimmunity</topic><topic>Autoimmunity - immunology</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Development and progression</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Esophageal Achalasia - immunology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology</topic><topic>Glutamate</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroglia - immunology</topic><topic>Neurons</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Radioimmunoprecipitation Assay</topic><topic>Retrospective Studies</topic><topic>Transplant Surgery</topic><topic>Type 1 diabetes</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kraichely, Robert E.</creatorcontrib><creatorcontrib>Farrugia, Gianrico</creatorcontrib><creatorcontrib>Pittock, Sean J.</creatorcontrib><creatorcontrib>Castell, Donald O.</creatorcontrib><creatorcontrib>Lennon, Vanda A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kraichely, Robert E.</au><au>Farrugia, Gianrico</au><au>Pittock, Sean J.</au><au>Castell, Donald O.</au><au>Lennon, Vanda A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural Autoantibody Profile of Primary Achalasia</atitle><jtitle>Digestive diseases and sciences</jtitle><stitle>Dig Dis Sci</stitle><addtitle>Dig Dis Sci</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>55</volume><issue>2</issue><spage>307</spage><epage>311</epage><pages>307-311</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>The etiology and pathogenesis of primary achalasia are both unknown. Postulated mechanisms include autoimmune, viral-immune, and central neurodegenerative. The aim of this study is to investigate the serum profile of neural autoantibodies in patients with primary achalasia. Coded sera from 70 patients with primary achalasia and 161 healthy control subjects, matched in sex, age, and smoking habits, were screened for antibodies targeting neuronal, glial, and muscle autoantigens. No specific myenteric neuronal antibody was identified. However, the overall prevalence of neural autoantibodies in patients with primary achalasia was significantly higher than in healthy control subjects (25.7 vs. 4.4%,
P
< 0.0001). Most noteworthy was the 21.4% frequency of glutamic acid decarboxylase-65 antibody in patients with achalasia (versus 2.5% in control subjects), in the absence of diabetes or companion antibodies predictive of type 1 diabetes. This profile of autoantibodies suggests an autoimmune basis for a subset of primary achalasia.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>19499338</pmid><doi>10.1007/s10620-009-0838-9</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Achalasia Adolescent Adult Aged Aged, 80 and over Autoantibodies Autoantibodies - immunology Autoantigens Autoimmunity Autoimmunity - immunology Biochemistry Biological and medical sciences Blotting, Western Development and progression Enzyme-Linked Immunosorbent Assay Esophageal Achalasia - immunology Feeding. Feeding behavior Female Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Gastroenterology Glutamate Hepatology Humans Male Medicine Medicine & Public Health Middle Aged Neuroglia - immunology Neurons Oncology Original Article Radioimmunoprecipitation Assay Retrospective Studies Transplant Surgery Type 1 diabetes Vertebrates: anatomy and physiology, studies on body, several organs or systems Young Adult |
| title | Neural Autoantibody Profile of Primary Achalasia |
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