H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability

Investigations aimed at identifying regulators of nuclear architecture in Drosophila demonstrated that cells lacking H3K9 methylation and RNA interference (RNAi) pathway components displayed disorganized nucleoli, ribosomal DNA (rDNA) and satellite DNAs. The levels of H3K9 dimethylation (H3K9me2) in...

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Veröffentlicht in:	Nature cell biology 2007-01, Vol.9 (1), p.25-35
Hauptverfasser:	Peng, Jamy C., Karpen, Gary H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Cancer Research Cell Biology Cell Cycle Proteins - genetics Cell Nucleolus - genetics Chromosomal Proteins, Non-Histone - genetics Chromosomes Cohesins Developmental Biology DNA Methylation DNA, Ribosomal - metabolism DNA, Satellite - metabolism Drosophila Drosophila - genetics Drosophila Proteins - genetics Epigenetics Exocrine glands Genes Genomics Heterochromatin - genetics Heterochromatin - physiology Histones - metabolism Insects Life Sciences Methylation Microscopy Models, Genetic Mutants Mutation Nuclear Proteins - genetics Protein Inhibitors of Activated STAT - genetics Repressor Proteins - genetics Ribosomal DNA RNA Interference Stem Cells
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