Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells

Induced pluripotent stem (iPS) cells have been derived from fibroblast, stomach, and liver cultures at extremely low frequencies by ectopic expression of the transcription factors Oct4, Sox2, c- myc, and Klf4, a process coined direct or in vitro reprogramming [1–8]. iPS cells are molecularly and fun...

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Veröffentlicht in:	Current biology 2008-06, Vol.18 (12), p.890-894
Hauptverfasser:	Stadtfeld, Matthias, Brennand, Kristen, Hochedlinger, Konrad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Cells, Cultured Chimera Female Insulin-Secreting Cells - cytology Insulin-Secreting Cells - virology Kruppel-Like Factor 4 Lentivirus Lentivirus - genetics Lentivirus - metabolism Lentivirus - physiology Mice Pluripotent Stem Cells - cytology Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism STEMCELLS Teratoma Transcription Factors - genetics Transcription Factors - metabolism Transduction, Genetic
Online-Zugang:	Volltext
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