IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching

IL-4 signaling promotes IgE class switching through STAT6 activation and the induction of Ig germ-line ε (GLε) transcription. Previously, we and others identified a transcription factor, Nfil3, as a gene induced by IL-4 stimulation in B cells. However, the precise roles of nuclear factor, IL-3-regul...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-01, Vol.107 (2), p.821-826
Hauptverfasser:	Kashiwada, Masaki, Levy, Deborah M, McKeag, Lisa, Murray, Keri, Schröder, Andreas J, Canfield, Stephen M, Traver, Geri, Rothman, Paul B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B lymphocytes B-Lymphocytes - immunology Basic-Leucine Zipper Transcription Factors - deficiency Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - physiology Beta cells Biological Sciences CD4-Positive T-Lymphocytes - immunology Cytokines Gene expression Gene expression regulation Genes Immunoglobulin E - genetics Immunoglobulin E - immunology Immunoglobulin Switch Region - genetics Immunoglobulin Switch Region - immunology Interleukin-4 - pharmacology Interleukin-4 - physiology Killer Cells, Natural - immunology Lymphocytes Mast cells Mice Mice, Inbred BALB C - genetics Mice, Inbred C57BL Mice, Knockout Myeloid cells Natural killer cells Rodents Transcription factors Transcriptional regulatory elements
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!