Mindfulness meditation training to reduce symptom distress in transplant patients: rationale, design, and experience with a recycled waitlist
Background Solid organ transplant recipients must take immune suppressive medications that have side effects, cause complications, and lead to distressing symptoms that reduce health-related quality of life (QOL). Mindfulness meditation has been shown to reduce these symptoms in other patient popula...
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description | Background Solid organ transplant recipients must take immune suppressive medications that have side effects, cause complications, and lead to distressing symptoms that reduce health-related quality of life (QOL). Mindfulness meditation has been shown to reduce these symptoms in other patient populations, and it is unlikely to interfere with the immune suppressive medication regimen.
Purpose This article describes the design and rationale of a clinical trial to determine whether training in mindfulness meditation can reduce depression, anxiety and insomnia after transplantation, and summarizes baseline characteristics of the participants.
Methods Transplant recipients were randomized in equal numbers to one of three arms: a Mindfulness-based Stress Reduction (MBSR) program consisting of 8 weeks of group instruction, home practice and telephone monitoring; a time and attention control Health Education program; or a waitlist arm. After serving 6 months as waitlist controls, these participants were re-randomized to MBSR or Health Education. Evaluations were obtained at baseline (prior to the active interventions), 8 weeks, 6 months, and 1 year (after randomization to MBSR or Health Education only). The primary analysis will compare composite symptom scores between MBSR and Health Education, initially or after serving in the waitlist. Subsequent analyses will compare these two groups on depression, anxiety, and insomnia symptom scales and secondary outcomes of health-related QOL, actigraphy, and health care utilization. A separate analysis, using only data collected before re-randomization, will compare short-term outcomes between the waitlist and active treatment arms.
Results One hundred fifty recipients were randomized and 72% of waitlist participants (31/43) were recycled to an active intervention after 6 months. Patient characteristics were balanced across trial arms after initial and secondary randomizations.
Limitations Transplant recipients are a very select population. Their adherence to the intervention and willingness to serve as waitlist controls prior to re-randomization may be atypical. Participants were not blinded to treatment and primary outcomes are self-reports.
Conclusion The innovative design used in the trial enabled the waitlist group to directly contribute to the number in the primary analysis of active arms, and to also serve as an internal validation test. The trial may be a useful model for trials involving very small target populati |
doi_str_mv | 10.1177/1740774508100982 |
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Purpose This article describes the design and rationale of a clinical trial to determine whether training in mindfulness meditation can reduce depression, anxiety and insomnia after transplantation, and summarizes baseline characteristics of the participants.
Methods Transplant recipients were randomized in equal numbers to one of three arms: a Mindfulness-based Stress Reduction (MBSR) program consisting of 8 weeks of group instruction, home practice and telephone monitoring; a time and attention control Health Education program; or a waitlist arm. After serving 6 months as waitlist controls, these participants were re-randomized to MBSR or Health Education. Evaluations were obtained at baseline (prior to the active interventions), 8 weeks, 6 months, and 1 year (after randomization to MBSR or Health Education only). The primary analysis will compare composite symptom scores between MBSR and Health Education, initially or after serving in the waitlist. Subsequent analyses will compare these two groups on depression, anxiety, and insomnia symptom scales and secondary outcomes of health-related QOL, actigraphy, and health care utilization. A separate analysis, using only data collected before re-randomization, will compare short-term outcomes between the waitlist and active treatment arms.
Results One hundred fifty recipients were randomized and 72% of waitlist participants (31/43) were recycled to an active intervention after 6 months. Patient characteristics were balanced across trial arms after initial and secondary randomizations.
Limitations Transplant recipients are a very select population. Their adherence to the intervention and willingness to serve as waitlist controls prior to re-randomization may be atypical. Participants were not blinded to treatment and primary outcomes are self-reports.
Conclusion The innovative design used in the trial enabled the waitlist group to directly contribute to the number in the primary analysis of active arms, and to also serve as an internal validation test. The trial may be a useful model for trials involving very small target populations. Clinical Trials 2009; 6: 76—89. http://ctj.sagepub.com</description><identifier>ISSN: 1740-7745</identifier><identifier>EISSN: 1740-7753</identifier><identifier>DOI: 10.1177/1740774508100982</identifier><identifier>PMID: 19254938</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Anxiety ; Clinical trials ; Depression - prevention & control ; Design of experiments ; Disease Management ; Health Education ; Humans ; Informed Consent ; Insomnia ; Meditation ; Mental depression ; Organ Transplantation - psychology ; Patients ; Randomized Controlled Trials as Topic ; Research Design ; Sample Size ; Sleep Initiation and Maintenance Disorders - prevention & control ; Stress, Psychological - prevention & control ; Transplants & implants ; Waiting Lists</subject><ispartof>Clinical trials (London, England), 2009-02, Vol.6 (1), p.76-89</ispartof><rights>SAGE Publications © Feb 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-af6e92f0a6f4721189172b866ffd1220612dd9603f2e4ea71c2da455cfcffb823</citedby><cites>FETCH-LOGICAL-c459t-af6e92f0a6f4721189172b866ffd1220612dd9603f2e4ea71c2da455cfcffb823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1740774508100982$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1740774508100982$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,315,782,786,887,21826,27931,27932,43628,43629</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19254938$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gross, Cynthia R</creatorcontrib><creatorcontrib>Kreitzer, Mary Jo</creatorcontrib><creatorcontrib>Reilly-Spong, Maryanne</creatorcontrib><creatorcontrib>Winbush, Nicole Y</creatorcontrib><creatorcontrib>Schomaker, E Katherine</creatorcontrib><creatorcontrib>Thomas, William</creatorcontrib><title>Mindfulness meditation training to reduce symptom distress in transplant patients: rationale, design, and experience with a recycled waitlist</title><title>Clinical trials (London, England)</title><addtitle>Clin Trials</addtitle><description>Background Solid organ transplant recipients must take immune suppressive medications that have side effects, cause complications, and lead to distressing symptoms that reduce health-related quality of life (QOL). Mindfulness meditation has been shown to reduce these symptoms in other patient populations, and it is unlikely to interfere with the immune suppressive medication regimen.
Purpose This article describes the design and rationale of a clinical trial to determine whether training in mindfulness meditation can reduce depression, anxiety and insomnia after transplantation, and summarizes baseline characteristics of the participants.
Methods Transplant recipients were randomized in equal numbers to one of three arms: a Mindfulness-based Stress Reduction (MBSR) program consisting of 8 weeks of group instruction, home practice and telephone monitoring; a time and attention control Health Education program; or a waitlist arm. After serving 6 months as waitlist controls, these participants were re-randomized to MBSR or Health Education. Evaluations were obtained at baseline (prior to the active interventions), 8 weeks, 6 months, and 1 year (after randomization to MBSR or Health Education only). The primary analysis will compare composite symptom scores between MBSR and Health Education, initially or after serving in the waitlist. Subsequent analyses will compare these two groups on depression, anxiety, and insomnia symptom scales and secondary outcomes of health-related QOL, actigraphy, and health care utilization. A separate analysis, using only data collected before re-randomization, will compare short-term outcomes between the waitlist and active treatment arms.
Results One hundred fifty recipients were randomized and 72% of waitlist participants (31/43) were recycled to an active intervention after 6 months. Patient characteristics were balanced across trial arms after initial and secondary randomizations.
Limitations Transplant recipients are a very select population. Their adherence to the intervention and willingness to serve as waitlist controls prior to re-randomization may be atypical. Participants were not blinded to treatment and primary outcomes are self-reports.
Conclusion The innovative design used in the trial enabled the waitlist group to directly contribute to the number in the primary analysis of active arms, and to also serve as an internal validation test. The trial may be a useful model for trials involving very small target populations. Clinical Trials 2009; 6: 76—89. http://ctj.sagepub.com</description><subject>Anxiety</subject><subject>Clinical trials</subject><subject>Depression - prevention & control</subject><subject>Design of experiments</subject><subject>Disease Management</subject><subject>Health Education</subject><subject>Humans</subject><subject>Informed Consent</subject><subject>Insomnia</subject><subject>Meditation</subject><subject>Mental depression</subject><subject>Organ Transplantation - psychology</subject><subject>Patients</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Research Design</subject><subject>Sample Size</subject><subject>Sleep Initiation and Maintenance Disorders - prevention & control</subject><subject>Stress, Psychological - prevention & control</subject><subject>Transplants & implants</subject><subject>Waiting Lists</subject><issn>1740-7745</issn><issn>1740-7753</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kU1vVCEUhonR2Dq6d2WIC1e9CtwPwEUT0_iV1LjRNWHgMKW5F67Atc6P6H8u05m02sQVBJ7zcA4vQi8peUsp5-8o7wjnXU8EJUQK9ggd744azvv28d2-64_Qs5wvCWGiF-1TdEQl6zvZimN0_c0H65YxQM54AuuLLj4GXJL2wYcNLhEnsIsBnLfTXOKErc8l7XB_i4U8jzoUPNdCCCW_x-lWoUc4wRay34QTrIPF8GeGVJGquvLlAusqNlszgsVX2pexap-jJ06PGV4c1hX6-enjj7Mvzfn3z1_PPpw3putlabQbQDJH9OA6zigVknK2FsPgnKWMkYEya-VAWsegA82pYVZ3fW-ccW4tWLtCp3vvvKzr0Kb2nfSo5uQnnbYqaq_-vQn-Qm3ib8UEFZy3VfDmIEjx1wK5qMlnA2P9CYhLVsMgJWU1hRV6_QC8jEuqn5NVbZQJSbisENlDJsWcE7i7TihRu6DVw6Bryau_J7gvOCRbgWYPZL2B-0f_K7wBkES0mQ</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Gross, Cynthia R</creator><creator>Kreitzer, Mary Jo</creator><creator>Reilly-Spong, Maryanne</creator><creator>Winbush, Nicole Y</creator><creator>Schomaker, E Katherine</creator><creator>Thomas, William</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PADUT</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090201</creationdate><title>Mindfulness meditation training to reduce symptom distress in transplant patients: rationale, design, and experience with a recycled waitlist</title><author>Gross, Cynthia R ; 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Mindfulness meditation has been shown to reduce these symptoms in other patient populations, and it is unlikely to interfere with the immune suppressive medication regimen.
Purpose This article describes the design and rationale of a clinical trial to determine whether training in mindfulness meditation can reduce depression, anxiety and insomnia after transplantation, and summarizes baseline characteristics of the participants.
Methods Transplant recipients were randomized in equal numbers to one of three arms: a Mindfulness-based Stress Reduction (MBSR) program consisting of 8 weeks of group instruction, home practice and telephone monitoring; a time and attention control Health Education program; or a waitlist arm. After serving 6 months as waitlist controls, these participants were re-randomized to MBSR or Health Education. Evaluations were obtained at baseline (prior to the active interventions), 8 weeks, 6 months, and 1 year (after randomization to MBSR or Health Education only). The primary analysis will compare composite symptom scores between MBSR and Health Education, initially or after serving in the waitlist. Subsequent analyses will compare these two groups on depression, anxiety, and insomnia symptom scales and secondary outcomes of health-related QOL, actigraphy, and health care utilization. A separate analysis, using only data collected before re-randomization, will compare short-term outcomes between the waitlist and active treatment arms.
Results One hundred fifty recipients were randomized and 72% of waitlist participants (31/43) were recycled to an active intervention after 6 months. Patient characteristics were balanced across trial arms after initial and secondary randomizations.
Limitations Transplant recipients are a very select population. Their adherence to the intervention and willingness to serve as waitlist controls prior to re-randomization may be atypical. Participants were not blinded to treatment and primary outcomes are self-reports.
Conclusion The innovative design used in the trial enabled the waitlist group to directly contribute to the number in the primary analysis of active arms, and to also serve as an internal validation test. The trial may be a useful model for trials involving very small target populations. Clinical Trials 2009; 6: 76—89. http://ctj.sagepub.com</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>19254938</pmid><doi>10.1177/1740774508100982</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Anxiety Clinical trials Depression - prevention & control Design of experiments Disease Management Health Education Humans Informed Consent Insomnia Meditation Mental depression Organ Transplantation - psychology Patients Randomized Controlled Trials as Topic Research Design Sample Size Sleep Initiation and Maintenance Disorders - prevention & control Stress, Psychological - prevention & control Transplants & implants Waiting Lists |
title | Mindfulness meditation training to reduce symptom distress in transplant patients: rationale, design, and experience with a recycled waitlist |
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