Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis

Serine proteases released from neutrophils are central to the pathogenesis of cystic fibrosis lung disease and are considered to be obvious therapeutic targets. Neutrophil elastase digests key opsonins present in the lung and disrupts phagocytosis, allowing bacteria to persist despite established pu...

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Veröffentlicht in:The European respiratory journal 2010-02, Vol.35 (2), p.410-417
Hauptverfasser: Farberman, M. M, Akers, K. T, Malone, J. P, Erdman-Gilmore, P, Townsend, R. R, Ferkol, T
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Sprache:eng
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