Sample sizes for brain atrophy outcomes in trials for secondary progressive multiple sclerosis

Progressive brain atrophy in multiple sclerosis (MS) may reflect neuroaxonal and myelin loss and MRI measures of brain tissue loss are used as outcome measures in MS treatment trials. This study investigated sample sizes required to demonstrate reduction of brain atrophy using three outcome measures...

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Veröffentlicht in:	Neurology 2009-02, Vol.72 (7), p.595-601
Hauptverfasser:	ALTMANN, D. R, JASPERSE, B, WAGNER, K, YOUSRY, T. A, MILLER, D. H, BARKHOF, F, BECKMANN, K, FILIPPI, M, KAPPOS, L. D, MOLYNEUX, P, POLMAN, C. H, POZZILLI, C, THOMPSON, A. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Atrophy - pathology Biological and medical sciences Brain - pathology Cohort Studies Diffusion Magnetic Resonance Imaging - methods Female Follow-Up Studies Humans Male Medical sciences Middle Aged Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Multiple Sclerosis, Chronic Progressive - epidemiology Multiple Sclerosis, Chronic Progressive - pathology Neurology Sample Size Treatment Outcome
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