Size-tunable synthesis of stable superparamagnetic iron oxide nanoparticles for potential biomedical applications
Dextran‐coated superparamagnetic nanoparticles (MNPs) have widespread biomedical applications. The superparamagnetic behavior, specifically regulated size, and smooth morphology are crucial requirements for essentially all of these applications. Presented herein is an innovative double‐coating strat...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2010-03, Vol.92A (4), p.1468-1475 |
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| creator | Yu, Faquan Yang, Victor C. |
| description | Dextran‐coated superparamagnetic nanoparticles (MNPs) have widespread biomedical applications. The superparamagnetic behavior, specifically regulated size, and smooth morphology are crucial requirements for essentially all of these applications. Presented herein is an innovative double‐coating strategy that would allow for a size‐controlled synthesis of MNPs. Small monocrystalline iron oxide nanoparticles (MIONs) were first synthesized, which served as the source of superparamagnetic properties. These MIONs were then treated in an acetate buffer containing biocompatible dextran polymer. Under such an environment, the colloidal MIONs would be quickly agglomerated by the acetate ions, and the formed coalescent body of MION would then be stabilized simultaneously by coating with dextran. By regulating the MION or dextran concentration as well as the thermal incubation time, the sizes of these first formed nanoparticles (termed 1st‐NPs) could be readily controlled. A second dextran coating step was further applied to smoothen the 1st‐NPs in attaining a final product (termed 2nd‐NPs). The 2nd‐NPs exhibited robust storage stability because of the additional coating shell. Results successfully confirmed the plausibility of this approach, as these MNPs displayed not only a smooth outline and a narrow size distribution but also the essential superparamagnetic behavior and a significantly prolonged stability on storage. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010 |
| doi_str_mv | 10.1002/jbm.a.32489 |
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The superparamagnetic behavior, specifically regulated size, and smooth morphology are crucial requirements for essentially all of these applications. Presented herein is an innovative double‐coating strategy that would allow for a size‐controlled synthesis of MNPs. Small monocrystalline iron oxide nanoparticles (MIONs) were first synthesized, which served as the source of superparamagnetic properties. These MIONs were then treated in an acetate buffer containing biocompatible dextran polymer. Under such an environment, the colloidal MIONs would be quickly agglomerated by the acetate ions, and the formed coalescent body of MION would then be stabilized simultaneously by coating with dextran. By regulating the MION or dextran concentration as well as the thermal incubation time, the sizes of these first formed nanoparticles (termed 1st‐NPs) could be readily controlled. A second dextran coating step was further applied to smoothen the 1st‐NPs in attaining a final product (termed 2nd‐NPs). The 2nd‐NPs exhibited robust storage stability because of the additional coating shell. Results successfully confirmed the plausibility of this approach, as these MNPs displayed not only a smooth outline and a narrow size distribution but also the essential superparamagnetic behavior and a significantly prolonged stability on storage. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010</description><identifier>ISSN: 1549-3296</identifier><identifier>ISSN: 1552-4965</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.32489</identifier><identifier>PMID: 19402138</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Acetates ; Biomedical materials ; Coated Materials, Biocompatible - chemical synthesis ; Coated Materials, Biocompatible - chemistry ; Coating ; Condensed matter: electronic structure, electrical, magnetic, and optical properties ; Crystallization ; Dextrans ; Dextrans - chemistry ; double coating ; Exact sciences and technology ; Ferric Compounds - chemistry ; Iron oxides ; Magnetic properties and materials ; Magnetics ; Materials Testing ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - ultrastructure ; Nanoparticles ; Particle Size ; Physics ; Reproduction ; size regulation ; Small particles and nanoscale materials ; stable storage ; Studies of specific magnetic materials ; superparamagnetic nanoparticle ; Surface Properties ; Synthesis</subject><ispartof>Journal of biomedical materials research. 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Part A</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Dextran‐coated superparamagnetic nanoparticles (MNPs) have widespread biomedical applications. The superparamagnetic behavior, specifically regulated size, and smooth morphology are crucial requirements for essentially all of these applications. Presented herein is an innovative double‐coating strategy that would allow for a size‐controlled synthesis of MNPs. Small monocrystalline iron oxide nanoparticles (MIONs) were first synthesized, which served as the source of superparamagnetic properties. These MIONs were then treated in an acetate buffer containing biocompatible dextran polymer. Under such an environment, the colloidal MIONs would be quickly agglomerated by the acetate ions, and the formed coalescent body of MION would then be stabilized simultaneously by coating with dextran. By regulating the MION or dextran concentration as well as the thermal incubation time, the sizes of these first formed nanoparticles (termed 1st‐NPs) could be readily controlled. A second dextran coating step was further applied to smoothen the 1st‐NPs in attaining a final product (termed 2nd‐NPs). The 2nd‐NPs exhibited robust storage stability because of the additional coating shell. Results successfully confirmed the plausibility of this approach, as these MNPs displayed not only a smooth outline and a narrow size distribution but also the essential superparamagnetic behavior and a significantly prolonged stability on storage. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010</description><subject>Acetates</subject><subject>Biomedical materials</subject><subject>Coated Materials, Biocompatible - chemical synthesis</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Coating</subject><subject>Condensed matter: electronic structure, electrical, magnetic, and optical properties</subject><subject>Crystallization</subject><subject>Dextrans</subject><subject>Dextrans - chemistry</subject><subject>double coating</subject><subject>Exact sciences and technology</subject><subject>Ferric Compounds - chemistry</subject><subject>Iron oxides</subject><subject>Magnetic properties and materials</subject><subject>Magnetics</subject><subject>Materials Testing</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - ultrastructure</subject><subject>Nanoparticles</subject><subject>Particle Size</subject><subject>Physics</subject><subject>Reproduction</subject><subject>size regulation</subject><subject>Small particles and nanoscale materials</subject><subject>stable storage</subject><subject>Studies of specific magnetic materials</subject><subject>superparamagnetic nanoparticle</subject><subject>Surface Properties</subject><subject>Synthesis</subject><issn>1549-3296</issn><issn>1552-4965</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoqVw4o5yQSChLP6OfUGiBQpoC4IWcbQmjtO6JHZqZ6HLr8dtlgUu5eTRzDMz7_gtiocYLTBC5Pl5MyxgQQmT6laxizknFVOC376KmaooUWKnuJfSeYYF4uRusYMVQwRTuVtcHLuftppWHprelmntpzObXCpDV6Zpzq1GG0eIMMCpt5MzpYvBl-HStbb04EOu5WxvU9mFWI5hsn5y0JeNC4NtnckhjGOfg8kFn-4Xdzrok32wefeKL29enxy8rZYfD98dvFxWhstaVbJhAtoGjDDGdBhRzKBDplVAcI1bRfJdLccZ5gjVsgEriKqJgRZhjAWle8WLee64arIOk1VF6PUY3QBxrQM4_W_FuzN9Gr5rIrHEVOQBTzYDYrhY2TTpwSVj-x68DaukpaSISETR_0mheM3ZtainN5JY1JgwxATJ6LMZNTGkFG23lY6RvjJeZ-M16GvjM_3o72v_sBunM_B4A0DKlnQRvHFpyxHCWP5Hnjk8cz9cb9c37dTv949-L6_mHpcme7ntgfhNi5rWXH_9cKiPyOdPy5P9Y_2K_gJ7PNgc</recordid><startdate>20100315</startdate><enddate>20100315</enddate><creator>Yu, Faquan</creator><creator>Yang, Victor C.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope><scope>L7M</scope><scope>7QO</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20100315</creationdate><title>Size-tunable synthesis of stable superparamagnetic iron oxide nanoparticles for potential biomedical applications</title><author>Yu, Faquan ; Yang, Victor C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5879-8b46adbac6cccf10314af0cd9a2171d92329d51c5850078bae62972cad0111633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acetates</topic><topic>Biomedical materials</topic><topic>Coated Materials, Biocompatible - chemical synthesis</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Coating</topic><topic>Condensed matter: electronic structure, electrical, magnetic, and optical properties</topic><topic>Crystallization</topic><topic>Dextrans</topic><topic>Dextrans - chemistry</topic><topic>double coating</topic><topic>Exact sciences and technology</topic><topic>Ferric Compounds - chemistry</topic><topic>Iron oxides</topic><topic>Magnetic properties and materials</topic><topic>Magnetics</topic><topic>Materials Testing</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - ultrastructure</topic><topic>Nanoparticles</topic><topic>Particle Size</topic><topic>Physics</topic><topic>Reproduction</topic><topic>size regulation</topic><topic>Small particles and nanoscale materials</topic><topic>stable storage</topic><topic>Studies of specific magnetic materials</topic><topic>superparamagnetic nanoparticle</topic><topic>Surface Properties</topic><topic>Synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Faquan</creatorcontrib><creatorcontrib>Yang, Victor C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biomedical materials research. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Faquan</au><au>Yang, Victor C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Size-tunable synthesis of stable superparamagnetic iron oxide nanoparticles for potential biomedical applications</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2010-03-15</date><risdate>2010</risdate><volume>92A</volume><issue>4</issue><spage>1468</spage><epage>1475</epage><pages>1468-1475</pages><issn>1549-3296</issn><issn>1552-4965</issn><eissn>1552-4965</eissn><abstract>Dextran‐coated superparamagnetic nanoparticles (MNPs) have widespread biomedical applications. The superparamagnetic behavior, specifically regulated size, and smooth morphology are crucial requirements for essentially all of these applications. Presented herein is an innovative double‐coating strategy that would allow for a size‐controlled synthesis of MNPs. Small monocrystalline iron oxide nanoparticles (MIONs) were first synthesized, which served as the source of superparamagnetic properties. These MIONs were then treated in an acetate buffer containing biocompatible dextran polymer. Under such an environment, the colloidal MIONs would be quickly agglomerated by the acetate ions, and the formed coalescent body of MION would then be stabilized simultaneously by coating with dextran. By regulating the MION or dextran concentration as well as the thermal incubation time, the sizes of these first formed nanoparticles (termed 1st‐NPs) could be readily controlled. A second dextran coating step was further applied to smoothen the 1st‐NPs in attaining a final product (termed 2nd‐NPs). The 2nd‐NPs exhibited robust storage stability because of the additional coating shell. 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| subjects | Acetates Biomedical materials Coated Materials, Biocompatible - chemical synthesis Coated Materials, Biocompatible - chemistry Coating Condensed matter: electronic structure, electrical, magnetic, and optical properties Crystallization Dextrans Dextrans - chemistry double coating Exact sciences and technology Ferric Compounds - chemistry Iron oxides Magnetic properties and materials Magnetics Materials Testing Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Nanoparticles Particle Size Physics Reproduction size regulation Small particles and nanoscale materials stable storage Studies of specific magnetic materials superparamagnetic nanoparticle Surface Properties Synthesis |
| title | Size-tunable synthesis of stable superparamagnetic iron oxide nanoparticles for potential biomedical applications |
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