Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts

Abstract The matricellular protein thrombospondin-2 (TSP2) has context-dependent effects on osteoblast lineage proliferation and differentiation. Mice lacking TSP2 display increased endocortical bone thickness, which is associated with increased marrow stromal cell (MSC) number and in vitro prolifer...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2010-02, Vol.46 (2), p.464-471
Hauptverfasser:	Alford, Andrea I, Terkhorn, Shawn P, Reddy, Anita B, Hankenson, Kurt D
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological and medical sciences Biomarkers - metabolism Calcification, Physiologic - physiology Cell Count Cell Differentiation Cell physiology Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Extracellular Matrix - genetics Extracellular Matrix - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation Matricellular Mice Mineralization Mineralization, calcification Molecular and cellular biology Organ Specificity Orthopedics Osteoblast Osteoblasts - cytology Osteoblasts - metabolism Osteocalcin RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism Sp7 Transcription Factor Thrombospondin-2 Thrombospondins - genetics Thrombospondins - metabolism Time Factors Transcription Factors - genetics Transcription Factors - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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