Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis

Heparan sulfate (HS) proteoglycans (HSPGs) bind to multiple growth factors/morphogens and regulate their signaling. 6 -O -sulfation (6S) of glucosamine within HS chains is critical for many of these ligand interactions. Sulf-1 and Sulf-2, which are extracellular neutral-pH sulfatases, provide a nove...

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Veröffentlicht in:	Oncogene 2010-02, Vol.29 (5), p.635-646
Hauptverfasser:	Lemjabbar-Alaoui, H, van Zante, A, Singer, M S, Xue, Q, Wang, Y -Q, Tsay, D, He, B, Jablons, D M, Rosen, S D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Binding sites Biological and medical sciences Carcinoma, Non-Small-Cell Lung - enzymology Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - pathology Cell Biology Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - metabolism Cellular signal transduction Data Mining Esterases Fundamental and applied biological sciences. Psychology Gene Expression Genetics Human Genetics Humans Immunoblotting Immunohistochemistry Internal Medicine Lung cancer Lung Neoplasms - enzymology Lung Neoplasms - pathology Male Medical sciences Medicine Medicine & Public Health Mice Mice, Nude Molecular and cellular biology Oncology original-article Physiological aspects Pneumology Proteins Proteoglycans Reverse Transcriptase Polymerase Chain Reaction Risk factors RNA Interference Signal transduction Signal Transduction - physiology Sulfotransferases - metabolism Tumors of the respiratory system and mediastinum Wnt Proteins - metabolism Xenograft Model Antitumor Assays
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