BRCA1 Represses Amphiregulin Gene Expression

BRCA1, the breast cancer- and ovarian cancer-specific tumor suppressor, can be a transcriptional repressor or a transcriptional activator, depending on the promoter context. To identify the genes activated or repressed by BRCA1, we have analyzed microarray results from cells depleted of BRCA1 and re...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-02, Vol.70 (3), p.996-1005
Hauptverfasser:	LAMBER, Ekaterina P, HORWITZ, Andrew A, PARVIN, Jeffrey D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphiregulin Antineoplastic agents Binding Sites - genetics Biological and medical sciences Blotting, Western BRCA1 Protein - genetics BRCA1 Protein - metabolism Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Chromatin Immunoprecipitation Early Growth Response Protein 1 - genetics Early Growth Response Protein 1 - metabolism EGF Family of Proteins Gene Expression Profiling Gene Expression Regulation, Neoplastic Glycoproteins - genetics Glycoproteins - metabolism HeLa Cells Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Medical sciences Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Promoter Regions, Genetic - genetics Protein Binding Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism Tumors
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