Comparative gene expression analysis of avian embryonic facial structures reveals new candidates for human craniofacial disorders

Mammals and birds have common embryological facial structures, and appear to employ the same molecular genetic developmental toolkit. We utilized natural variation found in bird beaks to investigate what genes drive vertebrate facial morphogenesis. We employed cross-species microarrays to describe t...

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Veröffentlicht in:	Human molecular genetics 2010-03, Vol.19 (5), p.920-930
Hauptverfasser:	Brugmann, S.A., Powder, K.E., Young, N.M., Goodnough, L.H., Hahn, S.M., James, A.W., Helms, J.A., Lovett, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian Proteins - genetics Avian Proteins - metabolism Beak - embryology beaks Biological and medical sciences Birds - embryology Birds - genetics Body Patterning Bone morphogenetic proteins Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cell Differentiation Chick Embryo Chickens - metabolism Craniofacial Abnormalities - genetics Craniofacial syndromes DNA microarrays Embryo, Nonmammalian - metabolism Embryos Fibroblast growth factor receptor 2 Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental Genetics of eukaryotes. Biological and molecular evolution Humans Molecular and cellular biology Morphogenesis Msx2 protein Neural crest Signal transduction Skull Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism
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