Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex

The fine-scale structure of the majority of copy number variation (CNV) regions remains unknown. The killer immunoglobulin receptor (KIR) gene complex exhibits significant CNV. The evolutionary plasticity of the KIRs and their broad biomedical relevance makes it important to understand how these imm...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2010-03, Vol.19 (5), p.737-751
Hauptverfasser:	Traherne, James A., Martin, Maureen, Ward, Rosemary, Ohashi, Maki, Pellett, Fawnda, Gladman, Dafna, Middleton, Derek, Carrington, Mary, Trowsdale, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromosome Mapping copy number DNA structure Evolution Fundamental and applied biological sciences. Psychology Gene Dosage - genetics Gene Duplication Genes, Immunoglobulin - genetics Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Haplotypes Humans Hybrids Immunoglobulin receptors Killer cell immunoglobulin-like receptors KIR protein Molecular and cellular biology Multigene Family - genetics Pathogens Plasticity Receptors, KIR - genetics Recombination Transposons Typing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!