DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang,China

AIM:To investigate the role of metabolic enzyme and DNA repair genes in susceptibility of esophageal squamous cell carcinoma(ESCC). METHODS:A case-control study was designed with 454 samples from 128 ESCC patients and 326 gender, age and ethnicity-matched control subjects.Genotypes of 69 single nucl...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2010-02, Vol.16 (5), p.641-647
Hauptverfasser:	Ma, Wen-Jing, Lv, Guo-Dong, Zheng, Shu-Tao, Huang, Cong-Gai, Liu, Qing, Wang, Xing, Lin, Ren-Yong, Sheyhidin, Ilyar, Lu, Xiao-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Brief Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Case-Control Studies China Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Genetic Predisposition to Disease Genotype Humans Middle Aged Neoplasm Metastasis Polymorphism, Genetic Risk Factors Surveys and Questionnaires
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Zusammenfassung:	AIM:To investigate the role of metabolic enzyme and DNA repair genes in susceptibility of esophageal squamous cell carcinoma(ESCC). METHODS:A case-control study was designed with 454 samples from 128 ESCC patients and 326 gender, age and ethnicity-matched control subjects.Genotypes of 69 single nucleotide polymorphisms(SNPs)of metabolic enzyme(aldehyde dehydrogenase-2,ALDH2; alcohol dehydrogenase-1 B,ADHB1;Cytochrome P450 2A6,CYP2A6)and DNA repair capacity genes(excision repair cross complementing group 1,E...
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v16.i5.641