Dynamic regulation of ROCK in tumor cells controls CXCR4-driven adhesion events

CXCR4 is a chemokine receptor often found aberrantly expressed on metastatic tumor cells. To investigate CXCR4 signaling in tumor cell adhesion, we stably overexpressed CXCR4 in MCF7 breast tumor cells. Cell attachment assays demonstrate that stimulation of the receptor with its ligand, CXCL12, prom...

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Veröffentlicht in:	Journal of cell science 2010-02, Vol.123 (3), p.401-412
Hauptverfasser:	Struckhoff, Amanda P, Vitko, Jason R, Rana, Manish K, Davis, Carter T, Foderingham, Kamau E, Liu, Chi-Hsin, Vanhoy-Rhodes, Lyndsay, Elliot, Steven, Zhu, Yun, Burow, Matt, Worthylake, Rebecca A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - pharmacology Cell Adhesion - drug effects Cell Line, Tumor Cell Movement - drug effects Chemokine CXCL12 - pharmacology Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Flow Cytometry Humans Immunoblotting Immunohistochemistry Microscopy, Fluorescence Pyridines - pharmacology Receptors, CXCR4 - metabolism rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism
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