DNA Methylation Predicts Survival and Response to Therapy in Patients With Myelodysplastic Syndromes

The current classification systems of myelodysplastic syndromes (MDS), including the International Prognostic Scoring System (IPSS), do not fully reflect the molecular heterogeneity of the disease. Molecular characterization may predict clinical outcome and help stratify patients for targeted therap...

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Veröffentlicht in:	Journal of clinical oncology 2010-02, Vol.28 (4), p.605-613
Hauptverfasser:	LANLAN SHEN, KANTARJIAN, Hagop, KONDO, Yutaka, OKI, Yasuhiro, JELINEK, Jaroslav, SABA, Hussain, ESTEY, Eli, ISSA, Jean-Pierre J, YI GUO, LIN, E, JIANQIN SHAN, XUELIN HUANG, BERRY, Donald, AHMED, Saira, WEI ZHU, PIERCE, Sherry
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Clinical Trials, Phase III as Topic Cohort Studies CpG Islands Disease-Free Survival DNA Methylation Female Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Multicenter Studies as Topic Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - mortality Myelodysplastic Syndromes - therapy Neoplasm Staging Original Reports Polymerase Chain Reaction Randomized Controlled Trials as Topic Survival Rate Treatment Outcome Tumors Young Adult
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