Human IL6 enhances leptin action in mice

Aims/hypothesis Interleukin-6 is an inflammatory cytokine with pleiotropic effects upon nutrient homeostasis. Many reports show that circulating IL6 correlates with obesity and contributes to insulin resistance; however, IL6 can promote energy expenditure that improves glucose homeostasis. Methods W...

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Veröffentlicht in:	Diabetologia 2010-03, Vol.53 (3), p.525-535
Hauptverfasser:	Sadagurski, M, Norquay, L, Farhang, J, D'Aquino, K, Copps, K, White, M. F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Feed Animals Biological and medical sciences Crosses, Genetic Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucose - metabolism Homeostasis Human Physiology Humans Inflammation Insulin - metabolism Interleukin-6 - metabolism Internal Medicine Leptin - metabolism Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Mice, Obese Mice, Transgenic Obesity Obesity - metabolism Obesity - pathology
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