Association Between Disease-Free Survival and Overall Survival When Survival Is Prolonged After Recurrence in Patients Receiving Cytotoxic Adjuvant Therapy for Colon Cancer: Simulations Based on the 20,800 Patient ACCENT Data Set

We previously validated disease-free survival (DFS) as a surrogate for overall survival (OS) in fluorouracil-based adjuvant colon cancer clinical trials. New therapies have extended survival after recurrence from 1 to approximately 2 years. We examined the possible impact of this improvement on the...

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Veröffentlicht in:	Journal of clinical oncology 2010-01, Vol.28 (3), p.460-465
Hauptverfasser:	DE GRAMONT, Aimery, HUBBARD, Joleen, BLANKE, Charles D, BENSON, Al, QIQI DENG, ALBERTS, Steven R, ANDRE, Thierry, WOLMARK, Norman, GROTHEY, Axel, SARGENT, Daniel, QIAN SHI, O'CONNELL, Michael J, BUYSE, Marc, BENEDETTI, Jacqueline, BOT, Brian, O'CALLAGHAN, Chris, YOTHERS, Greg, GOLDBERG, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Chemotherapy, Adjuvant Colonic Neoplasms - drug therapy Colonic Neoplasms - mortality Colonic Neoplasms - surgery Disease-Free Survival Follow-Up Studies Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Neoplasm Recurrence, Local - mortality Original Reports Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Time Factors Tumors
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