Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma
BACKGROUND: The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma. METHODS: By using a cross‐sectional design, patients with clinically stable (10 ± 7 days p...
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| Veröffentlicht in: | Cancer 2010-02, Vol.116 (3), p.695-704 |
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| creator | Jones, Lee W. Friedman, Allan H. West, Miranda J. Mabe, Stephanie K. Fraser, Jennifer Kraus, William E. Friedman, Henry S. Tresch, Maura I. Major, Nancy Reardon, David A. |
| description | BACKGROUND:
The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma.
METHODS:
By using a cross‐sectional design, patients with clinically stable (10 ± 7 days postsurgery) high‐grade glioma (HGG; n = 25) or low‐grade glioma (LGG; n = 10) were studied. Participants performed a cardiopulmonary exercise test (CPET) with expired gas analysis to assess cardiorespiratory fitness (peak oxygen consumption, VO2peak). Other physiological outcomes included skeletal muscle cross‐sectional area (CSA; magnetic resonance imaging), isokinetic muscle strength (isokinetic dynamometer), and body composition (air displacement plethysmography). Quality of life was assessed with the Functional Assessment of Cancer Therapy‐Brain scale.
RESULTS:
CPET was a feasible and safe procedure to assess VO2peak, with no serious adverse events. VO2peak indexed to total body weight and lean body mass (LBM) for both groups was 13.0 mL · weight · min−1 and 19 mL · LBM · min−1, the equivalent to 59% and 38% below age‐ and sex‐predicted normative values, respectively. Skeletal muscle strength and mid‐thigh CSA were lower in HGG relative to LGG patients (83 vs 125 Nm, P = .025; 94 vs 119 cm2, P = .171, respectively). Skeletal muscle isokinetic strength, CSA, and body composition outcomes predicted VO2peak (r = −0.59 to 0.68, P < .05).
CONCLUSIONS:
Postsurgical glioma patients have markedly reduced cardiorespiratory fitness, isokinetic strength, and CSA. Prospective studies are now required to determine whether such abnormalities influence treatment toxicity and clinical outcome as well as to test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction. Cancer 2010. © 2009 American Cancer Society.
Postsurgical glioma patients have markedly reduced cardiorespiratory fitness, isokinetic strength, and cross‐sectional area. Prospective studies are now required to determine whether such abnormalities influence treatment toxicity and clinical outcome as well as to test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction. |
| doi_str_mv | 10.1002/cncr.24808 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2815124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>746051919</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4818-e21af24e566be023d99fb699f42fcaaa58cfe464fa03eefaa75e4b7f791ee23e3</originalsourceid><addsrcrecordid>eNp9kd2KFDEQhYMo7rh64wNIbkSQ7TVJp_9uBBn8g0VRFLwL1enKbDSdjEl6l3kHH9qMM656401CKl-dU8Uh5CFn55wx8Ux7Hc-F7Fl_i6w4G7qKcSlukxVjrK8aWX85IfdS-lqenWjqu-RElLZh6JoV-fFhAZ9thmyvkEJKmNKMPtNgqIY42RAxbW2EHOKOGpt9Ac5o-oYOMzg6L0k7pGbxOtvgzyj4iY5h2lEd5m1Idl-l1lOYFpcTvbb5km6jnaHIzeDsxhd_unE2zHCf3DHgEj443qfk86uXn9Zvqov3r9-uX1xUWva8r1BwMEJi07YjMlFPw2DGthxSGA0ATa8NylYaYDWiAegalGNnuoEjihrrU_L8oLtdxhknXfaN4NRxLBXAqn9_vL1Um3ClRM8bLmQReHIUiOH7gimr2SaNzoHHsCTVyZY1fOBDIZ8eSB1DShHNjQtnap-e2qenfqVX4Ed_z3WD_o6rAI-PACQNzkTw2qY_nKjbXnBeOH7grq3D3X8s1frd-uPB_Ce3Pbi6</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>746051919</pqid></control><display><type>article</type><title>Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Jones, Lee W. ; Friedman, Allan H. ; West, Miranda J. ; Mabe, Stephanie K. ; Fraser, Jennifer ; Kraus, William E. ; Friedman, Henry S. ; Tresch, Maura I. ; Major, Nancy ; Reardon, David A.</creator><creatorcontrib>Jones, Lee W. ; Friedman, Allan H. ; West, Miranda J. ; Mabe, Stephanie K. ; Fraser, Jennifer ; Kraus, William E. ; Friedman, Henry S. ; Tresch, Maura I. ; Major, Nancy ; Reardon, David A.</creatorcontrib><description>BACKGROUND:
The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma.
METHODS:
By using a cross‐sectional design, patients with clinically stable (10 ± 7 days postsurgery) high‐grade glioma (HGG; n = 25) or low‐grade glioma (LGG; n = 10) were studied. Participants performed a cardiopulmonary exercise test (CPET) with expired gas analysis to assess cardiorespiratory fitness (peak oxygen consumption, VO2peak). Other physiological outcomes included skeletal muscle cross‐sectional area (CSA; magnetic resonance imaging), isokinetic muscle strength (isokinetic dynamometer), and body composition (air displacement plethysmography). Quality of life was assessed with the Functional Assessment of Cancer Therapy‐Brain scale.
RESULTS:
CPET was a feasible and safe procedure to assess VO2peak, with no serious adverse events. VO2peak indexed to total body weight and lean body mass (LBM) for both groups was 13.0 mL · weight · min−1 and 19 mL · LBM · min−1, the equivalent to 59% and 38% below age‐ and sex‐predicted normative values, respectively. Skeletal muscle strength and mid‐thigh CSA were lower in HGG relative to LGG patients (83 vs 125 Nm, P = .025; 94 vs 119 cm2, P = .171, respectively). Skeletal muscle isokinetic strength, CSA, and body composition outcomes predicted VO2peak (r = −0.59 to 0.68, P < .05).
CONCLUSIONS:
Postsurgical glioma patients have markedly reduced cardiorespiratory fitness, isokinetic strength, and CSA. Prospective studies are now required to determine whether such abnormalities influence treatment toxicity and clinical outcome as well as to test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction. Cancer 2010. © 2009 American Cancer Society.
Postsurgical glioma patients have markedly reduced cardiorespiratory fitness, isokinetic strength, and cross‐sectional area. Prospective studies are now required to determine whether such abnormalities influence treatment toxicity and clinical outcome as well as to test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.24808</identifier><identifier>PMID: 20029975</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Body Composition ; Body Mass Index ; Brain Neoplasms - physiopathology ; cardiorespiratory fitness ; Fatigue ; Female ; Glioma - physiopathology ; Heart - physiopathology ; Humans ; Male ; malignant glioma ; Medical sciences ; Middle Aged ; Muscle Strength ; Muscle, Skeletal - pathology ; Muscle, Skeletal - physiopathology ; Neurology ; Oxygen Consumption ; Physical Fitness ; Quality of Life ; Respiration ; skeletal muscle function ; Tumors ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Cancer, 2010-02, Vol.116 (3), p.695-704</ispartof><rights>Copyright © 2009 American Cancer Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4818-e21af24e566be023d99fb699f42fcaaa58cfe464fa03eefaa75e4b7f791ee23e3</citedby><cites>FETCH-LOGICAL-c4818-e21af24e566be023d99fb699f42fcaaa58cfe464fa03eefaa75e4b7f791ee23e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.24808$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.24808$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22368211$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20029975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jones, Lee W.</creatorcontrib><creatorcontrib>Friedman, Allan H.</creatorcontrib><creatorcontrib>West, Miranda J.</creatorcontrib><creatorcontrib>Mabe, Stephanie K.</creatorcontrib><creatorcontrib>Fraser, Jennifer</creatorcontrib><creatorcontrib>Kraus, William E.</creatorcontrib><creatorcontrib>Friedman, Henry S.</creatorcontrib><creatorcontrib>Tresch, Maura I.</creatorcontrib><creatorcontrib>Major, Nancy</creatorcontrib><creatorcontrib>Reardon, David A.</creatorcontrib><title>Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND:
The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma.
METHODS:
By using a cross‐sectional design, patients with clinically stable (10 ± 7 days postsurgery) high‐grade glioma (HGG; n = 25) or low‐grade glioma (LGG; n = 10) were studied. Participants performed a cardiopulmonary exercise test (CPET) with expired gas analysis to assess cardiorespiratory fitness (peak oxygen consumption, VO2peak). Other physiological outcomes included skeletal muscle cross‐sectional area (CSA; magnetic resonance imaging), isokinetic muscle strength (isokinetic dynamometer), and body composition (air displacement plethysmography). Quality of life was assessed with the Functional Assessment of Cancer Therapy‐Brain scale.
RESULTS:
CPET was a feasible and safe procedure to assess VO2peak, with no serious adverse events. VO2peak indexed to total body weight and lean body mass (LBM) for both groups was 13.0 mL · weight · min−1 and 19 mL · LBM · min−1, the equivalent to 59% and 38% below age‐ and sex‐predicted normative values, respectively. Skeletal muscle strength and mid‐thigh CSA were lower in HGG relative to LGG patients (83 vs 125 Nm, P = .025; 94 vs 119 cm2, P = .171, respectively). Skeletal muscle isokinetic strength, CSA, and body composition outcomes predicted VO2peak (r = −0.59 to 0.68, P < .05).
CONCLUSIONS:
Postsurgical glioma patients have markedly reduced cardiorespiratory fitness, isokinetic strength, and CSA. Prospective studies are now required to determine whether such abnormalities influence treatment toxicity and clinical outcome as well as to test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction. Cancer 2010. © 2009 American Cancer Society.
Postsurgical glioma patients have markedly reduced cardiorespiratory fitness, isokinetic strength, and cross‐sectional area. Prospective studies are now required to determine whether such abnormalities influence treatment toxicity and clinical outcome as well as to test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Brain Neoplasms - physiopathology</subject><subject>cardiorespiratory fitness</subject><subject>Fatigue</subject><subject>Female</subject><subject>Glioma - physiopathology</subject><subject>Heart - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>malignant glioma</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle Strength</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Neurology</subject><subject>Oxygen Consumption</subject><subject>Physical Fitness</subject><subject>Quality of Life</subject><subject>Respiration</subject><subject>skeletal muscle function</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd2KFDEQhYMo7rh64wNIbkSQ7TVJp_9uBBn8g0VRFLwL1enKbDSdjEl6l3kHH9qMM656401CKl-dU8Uh5CFn55wx8Ux7Hc-F7Fl_i6w4G7qKcSlukxVjrK8aWX85IfdS-lqenWjqu-RElLZh6JoV-fFhAZ9thmyvkEJKmNKMPtNgqIY42RAxbW2EHOKOGpt9Ac5o-oYOMzg6L0k7pGbxOtvgzyj4iY5h2lEd5m1Idl-l1lOYFpcTvbb5km6jnaHIzeDsxhd_unE2zHCf3DHgEj443qfk86uXn9Zvqov3r9-uX1xUWva8r1BwMEJi07YjMlFPw2DGthxSGA0ATa8NylYaYDWiAegalGNnuoEjihrrU_L8oLtdxhknXfaN4NRxLBXAqn9_vL1Um3ClRM8bLmQReHIUiOH7gimr2SaNzoHHsCTVyZY1fOBDIZ8eSB1DShHNjQtnap-e2qenfqVX4Ed_z3WD_o6rAI-PACQNzkTw2qY_nKjbXnBeOH7grq3D3X8s1frd-uPB_Ce3Pbi6</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Jones, Lee W.</creator><creator>Friedman, Allan H.</creator><creator>West, Miranda J.</creator><creator>Mabe, Stephanie K.</creator><creator>Fraser, Jennifer</creator><creator>Kraus, William E.</creator><creator>Friedman, Henry S.</creator><creator>Tresch, Maura I.</creator><creator>Major, Nancy</creator><creator>Reardon, David A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20100201</creationdate><title>Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma</title><author>Jones, Lee W. ; Friedman, Allan H. ; West, Miranda J. ; Mabe, Stephanie K. ; Fraser, Jennifer ; Kraus, William E. ; Friedman, Henry S. ; Tresch, Maura I. ; Major, Nancy ; Reardon, David A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4818-e21af24e566be023d99fb699f42fcaaa58cfe464fa03eefaa75e4b7f791ee23e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Brain Neoplasms - physiopathology</topic><topic>cardiorespiratory fitness</topic><topic>Fatigue</topic><topic>Female</topic><topic>Glioma - physiopathology</topic><topic>Heart - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>malignant glioma</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle Strength</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Neurology</topic><topic>Oxygen Consumption</topic><topic>Physical Fitness</topic><topic>Quality of Life</topic><topic>Respiration</topic><topic>skeletal muscle function</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jones, Lee W.</creatorcontrib><creatorcontrib>Friedman, Allan H.</creatorcontrib><creatorcontrib>West, Miranda J.</creatorcontrib><creatorcontrib>Mabe, Stephanie K.</creatorcontrib><creatorcontrib>Fraser, Jennifer</creatorcontrib><creatorcontrib>Kraus, William E.</creatorcontrib><creatorcontrib>Friedman, Henry S.</creatorcontrib><creatorcontrib>Tresch, Maura I.</creatorcontrib><creatorcontrib>Major, Nancy</creatorcontrib><creatorcontrib>Reardon, David A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jones, Lee W.</au><au>Friedman, Allan H.</au><au>West, Miranda J.</au><au>Mabe, Stephanie K.</au><au>Fraser, Jennifer</au><au>Kraus, William E.</au><au>Friedman, Henry S.</au><au>Tresch, Maura I.</au><au>Major, Nancy</au><au>Reardon, David A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>116</volume><issue>3</issue><spage>695</spage><epage>704</epage><pages>695-704</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND:
The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma.
METHODS:
By using a cross‐sectional design, patients with clinically stable (10 ± 7 days postsurgery) high‐grade glioma (HGG; n = 25) or low‐grade glioma (LGG; n = 10) were studied. Participants performed a cardiopulmonary exercise test (CPET) with expired gas analysis to assess cardiorespiratory fitness (peak oxygen consumption, VO2peak). Other physiological outcomes included skeletal muscle cross‐sectional area (CSA; magnetic resonance imaging), isokinetic muscle strength (isokinetic dynamometer), and body composition (air displacement plethysmography). Quality of life was assessed with the Functional Assessment of Cancer Therapy‐Brain scale.
RESULTS:
CPET was a feasible and safe procedure to assess VO2peak, with no serious adverse events. VO2peak indexed to total body weight and lean body mass (LBM) for both groups was 13.0 mL · weight · min−1 and 19 mL · LBM · min−1, the equivalent to 59% and 38% below age‐ and sex‐predicted normative values, respectively. Skeletal muscle strength and mid‐thigh CSA were lower in HGG relative to LGG patients (83 vs 125 Nm, P = .025; 94 vs 119 cm2, P = .171, respectively). Skeletal muscle isokinetic strength, CSA, and body composition outcomes predicted VO2peak (r = −0.59 to 0.68, P < .05).
CONCLUSIONS:
Postsurgical glioma patients have markedly reduced cardiorespiratory fitness, isokinetic strength, and CSA. Prospective studies are now required to determine whether such abnormalities influence treatment toxicity and clinical outcome as well as to test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction. Cancer 2010. © 2009 American Cancer Society.
Postsurgical glioma patients have markedly reduced cardiorespiratory fitness, isokinetic strength, and cross‐sectional area. Prospective studies are now required to determine whether such abnormalities influence treatment toxicity and clinical outcome as well as to test the effect of appropriately selected interventions to prevent and/or mitigate dysfunction.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20029975</pmid><doi>10.1002/cncr.24808</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Body Composition Body Mass Index Brain Neoplasms - physiopathology cardiorespiratory fitness Fatigue Female Glioma - physiopathology Heart - physiopathology Humans Male malignant glioma Medical sciences Middle Aged Muscle Strength Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Neurology Oxygen Consumption Physical Fitness Quality of Life Respiration skeletal muscle function Tumors Tumors of the nervous system. Phacomatoses |
| title | Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma |
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