Methylation patterns of cell-free plasma DNA in relapsing–remitting multiple sclerosis

Abstract Background There is growing interest for identification of new targets for biomarker development in multiple sclerosis (MS). The goal of this study was to compare the concentration and the methylation patterns of cell-free plasma DNA (cfpDNA) in patients with relapsing–remitting multiple sc...

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Veröffentlicht in:	Journal of the neurological sciences 2010-03, Vol.290 (1), p.16-21
Hauptverfasser:	Liggett, Thomas, Melnikov, Anatoliy, Tilwalli, Shilpa, Yi, Qilong, Chen, Haiyan, Replogle, Charles, Feng, Xuan, Reder, Anthony, Stefoski, Dusan, Balabanov, Roumen, Levenson, Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Biomarker Biomarkers - analysis Biomarkers - blood Cell-free plasma DNA Cohort Studies DNA - analysis DNA - blood DNA methylation DNA Methylation - genetics DNA Mutational Analysis Epigenesis, Genetic - genetics Female Gene promoter Genetic Markers - genetics Genetic Testing Humans Male Medical sciences Microarray Middle Aged Multiple sclerosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Multiple Sclerosis, Relapsing-Remitting - blood Multiple Sclerosis, Relapsing-Remitting - diagnosis Multiple Sclerosis, Relapsing-Remitting - genetics Neurology Oligonucleotide Array Sequence Analysis Plasma - chemistry Plasma - metabolism Predictive Value of Tests Promoter Regions, Genetic - genetics Sensitivity and Specificity Up-Regulation - genetics
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