Preintegration HIV-1 Inhibition by a Combination Lentiviral Vector Containing a Chimeric TRIM5α Protein, a CCR5 shRNA, and a TAR Decoy

Human immunodeficiency virus (HIV) gene therapy offers a promising alternative approach to current antiretroviral treatments to inhibit HIV-1 infection. Various stages of the HIV life cycle including pre-entry, preintegration, and postintegration can be targeted by gene therapy to block viral infect...

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Veröffentlicht in:	Molecular therapy 2009-12, Vol.17 (12), p.2103-2114
Hauptverfasser:	Anderson, Joseph S, Javien, John, Nolta, Jan A, Bauer, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics CCR5 Receptor Antagonists Flow Cytometry Genetic Therapy Genetic Vectors - administration & dosage Hematopoietic Stem Cells - metabolism HIV - genetics HIV Infections - genetics HIV Infections - therapy HIV Infections - virology Humans Lentivirus - genetics Macaca mulatta Macrophages - metabolism Original Proteins - genetics Receptors, CCR5 - genetics rev Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors rev Gene Products, Human Immunodeficiency Virus - physiology RNA, Small Interfering - genetics tat Gene Products, Human Immunodeficiency Virus - antagonists & inhibitors tat Gene Products, Human Immunodeficiency Virus - physiology Transduction, Genetic Transgenes - physiology Ubiquitin-Protein Ligases Virus Integration
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