Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

Monozygotic (MZ) twins are partially concordant for most complex diseases, including autoimmune disorders. Whereas phenotypic concordance can be used to study heritability, discordance suggests the role of non-genetic factors. In autoimmune diseases, environmentally driven epigenetic changes are tho...

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Veröffentlicht in:	Genome research 2010-02, Vol.20 (2), p.170-179
Hauptverfasser:	Javierre, Biola M, Fernandez, Agustin F, Richter, Julia, Al-Shahrour, Fatima, Martin-Subero, J Ignacio, Rodriguez-Ubreva, Javier, Berdasco, Maria, Fraga, Mario F, O'Hanlon, Terrance P, Rider, Lisa G, Jacinto, Filipe V, Lopez-Longo, F Javier, Dopazo, Joaquin, Forn, Marta, Peinado, Miguel A, Carreño, Luis, Sawalha, Amr H, Harley, John B, Siebert, Reiner, Esteller, Manel, Miller, Frederick W, Ballestar, Esteban
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - chemistry Arthritis, Rheumatoid - genetics Autoimmune Diseases - genetics Cohort Studies CpG Islands - genetics Dermatomyositis - genetics Diseases in Twins - genetics DNA Methylation Female Genes, rRNA Humans Letter Lupus Erythematosus, Systemic - genetics Male Promoter Regions, Genetic Sequence Analysis, DNA - methods Twins, Monozygotic - genetics
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