Superoxide production by mitochondria of insulin-sensitive tissues: mechanistic differences and effect of early diabetes

Abstract Obesity and mild hyperglycemia are characteristic of early or “prediabetes.” The associated increase in fatty acid flux is posited to enhance substrate delivery to mitochondria, leading to enhanced superoxide production that results in mitochondrial dysfunction and progressive worsening of...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2010-02, Vol.59 (2), p.247-257
Hauptverfasser:	Herlein, Judy A, Fink, Brian D, Sivitz, William I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Dietary Fats - administration & dosage Electron Spin Resonance Spectroscopy Endocrine pancreas. Apud cells (diseases) Endocrinology & Metabolism Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Insulin - pharmacology Ion Channels - genetics Male Medical sciences Membrane Potential, Mitochondrial Mitochondria - metabolism Mitochondria, Heart - metabolism Mitochondria, Liver - metabolism Mitochondria, Muscle - metabolism Mitochondrial Proteins - genetics Muscle, Skeletal - ultrastructure Oxygen Consumption Rats Rats, Sprague-Dawley Superoxides - analysis Superoxides - metabolism Uncoupling Protein 3 Up-Regulation Vertebrates: anatomy and physiology, studies on body, several organs or systems
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