Entering the leinamycin rearrangement via 2-(trimethylsilyl)ethyl sulfoxides

Attack of cellular thiols on the antitumor natural product leinamycin is believed to generate a sulfenate intermediate that undergoes subsequent rearrangement to a DNA-alkylating episulfonium ion. Here, 2-(trimethylsilyl)ethyl sulfoxides were employed in a fluoride-triggered generation of sulfenate...

Ausführliche Beschreibung