Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway

Cytosolic internalization is a requirement for the toxicity of secretory ribonucleases. Here, we investigate the mechanism of internalization of Onconase (ONC), a toxic protein, and ribonuclease A (RNase A), a nontoxic homolog. Microscopy studies indicate that both ribonucleases readily bind to the...

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Veröffentlicht in:	Journal of cell science 2003-01, Vol.116 (Pt 2), p.313-324
Hauptverfasser:	Haigis, Marcia C, Raines, Ronald T
Format:	Artikel
Sprache:	eng
Schlagworte:	Bodily Secretions - physiology Cell Membrane - metabolism Cytosol - metabolism Cytotoxins - metabolism Cytotoxins - pharmacology Dynamins - metabolism Endocytosis - physiology Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endosomes - drug effects Endosomes - metabolism Eukaryotic Cells - enzymology Eukaryotic Cells - metabolism HeLa Cells Humans Models, Biological Molecular Structure Protein Transport - physiology Ribonuclease, Pancreatic - metabolism Ribonuclease, Pancreatic - pharmacology Ribonucleases - metabolism Ribonucleases - pharmacology Secretory Vesicles - metabolism Transferrin - metabolism
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