The Mycobacterium tuberculosis cytochrome P450 system

Tuberculosis remains a leading cause of human mortality. The emergence of strains of Mycobacterium tuberculosis, the causative agent, that are resistant to the major frontline antitubercular drugs increases the urgency for the development of new therapeutic agents. Sequencing of the M. tuberculosis...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2010-01, Vol.493 (1), p.82-95
Hauptverfasser:	Ouellet, Hugues, Johnston, Jonathan B., Ortiz de Montellano, Paul R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Azole drugs Cyclodipeptide CYP121 CYP128 CYP130 CYP51 Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 FprA Genomics Models, Molecular Mycobacterium tuberculosis Mycobacterium tuberculosis - enzymology Oxidation-Reduction Phylogeny Protein Conformation Proteomics Sulfolipid
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