Inhibition of vinyl carbamate-induced pulmonary adenocarcinoma by indole-3-carbinol and myo-inositol in A/J mice

In previous studies, we reported that indole-3-carbinol (I3C) and myo-inositol (MI) inhibit lung adenoma induced by tobacco smoke carcinogens in A/J mice. In this paper, we extended our work and examined the effects of I3C (70 or 30 μmol/g diet) and MI (56 μmol/g diet) against vinyl carbamate (VC)-i...

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Veröffentlicht in:	Carcinogenesis (New York) 2010-02, Vol.31 (2), p.239-245
Hauptverfasser:	Kassie, Fekadu, Kalscheuer, Stephen, Matise, Ilze, Ma, Linan, Melkamu, Tamene, Upadhyaya, Pramod, Hecht, Stephen S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemically induced Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Animals Anticarcinogenic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Blotting, Western Cancer Prevention Carcinogenesis, carcinogens and anticarcinogens Caspase 3 - metabolism Cell Proliferation - drug effects Chemical agents Cyclooxygenase 2 - metabolism Female Indoles - pharmacology Inositol - pharmacology Lung Neoplasms - chemically induced Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Medical sciences Mice Mice, Inbred A Poly(ADP-ribose) Polymerases - metabolism Tumors Urethane - analogs & derivatives Urethane - toxicity Vitamin B Complex
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